Evaluation of Serum Ischemia Modified Albumin Levels in Children Aged 1 Month-5 Years with a Diagnosis of Lower Respiratory Tract Infection
| Author | Meltem Yılmaz Aksoy | en |
| Author | Huseyin Dag | en |
| Author | Emine Turkkan | en |
| Author | Okan Dikker | en |
| Author | Adem Karbuz | en |
| Orcid | Meltem Yılmaz Aksoy [0000-0002-5312-0650] | en |
| Orcid | Huseyin Dag [0000-0001-7596-7687] | en |
| Orcid | Emine Turkkan [0000-0002-5126-7843] | en |
| Orcid | Okan Dikker [0000-0002-9153-6139] | en |
| Issued Date | 2026-04-30 | en |
| Abstract | Background: In our study, we aimed to compare serum ischemia modified albumin (IMA) levels in patients with lower respiratory tract infection (LRTI) between the ages of 1 month and 5 years and healthy children, to evaluate the correlation between serum IMA levels and other laboratory parameters in pneumonia and bronchiolitis subgroups, and also to evaluate the usefulness of serum IMA level as a diagnostic marker in these patients. Methods: A total of 85 patients, including 60 hospitalized patients with LRTI between the ages of 1 month and 5 years and 25 healthy children without any complaints or diseases who were admitted to the pediatric outpatient clinic for routine follow-up, were included in our study. The 60 patients with LRTI were separated into two groups as the pneumonia group (n = 30) and the bronchiolitis group (n = 30). Demographic characteristics, complaints, history, comorbidities, physical examination findings at the time of diagnosis, need for oxygen support, duration of hospitalization, and demographic characteristics of the control group were recorded. Hemogram, C-reactive protein (CRP), procalcitonin, routine biochemistry tests, and blood gas test results were recorded from all patients. Serum samples were analyzed by enzyme-linked immunosorbent assay (ELISA) for the measurement of IMA levels. The results were evaluated statistically. Statistical analyses were performed using SPSS 22.0. Depending on data distribution, appropriate parametric or non-parametric tests and ROC curve analysis were applied. Statistical significance was set at P < 0.05. Results: Serum IMA levels in the LRTI group (184.85 ± 117.51 ng/mL) were higher than those in the healthy control group (93.30 ± 57.73 ng/mL) (P < 0.05). However, there was no statistical difference in serum IMA levels between the bronchiolitis and pneumonia groups (P > 0.05). We found no significant correlation between IMA levels and various biochemical parameters in the LRTI, pneumonia, and bronchiolitis groups (P > 0.05). Conclusions: Serum IMA levels were found to be significantly elevated in pediatric patients diagnosed with LRTI. Serum IMA levels may be considered a biomarker in the diagnosis and exclusion of LRTI. However, the relatively small sample size and single-center design may limit the generalizability of our findings. | en |
| DOI | https://doi.org/10.5812/ijpediatr-165368 | en |
| Keyword | Ischemia Modified Albumin | en |
| Keyword | Children | en |
| Keyword | Respiratory Tract Infection | en |
| Publisher | Brieflands | en |
| Title | Evaluation of Serum Ischemia Modified Albumin Levels in Children Aged 1 Month-5 Years with a Diagnosis of Lower Respiratory Tract Infection | en |
| Type | Research Article | en |
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