In Vitro and In Vivo Antidiabetic, α-Glucosidase Inhibition and Antibacterial Activities of Three Brown Algae, <i>Polycladia myrica</i>, <i>Padina antillarum</i>, and <i>Sargassum boveanum</i>, and a Red Alga, <i>Palisada perforata</i> from the Persian Gulf
| Author | Niloofar Moheimanian | en |
| Author | Hossein Mirkhani | en |
| Author | Azar Purkhosrow | en |
| Author | Jelveh Sohrabipour | en |
| Author | Amir Reza Jassbi | en |
| Issued Date | 2023-12-31 | en |
| Abstract | Background: In recent decades, algae have attracted worldwide attention for their great biological activities, such as antidiabetic and antibacterial properties. Objectives: We measured antibacterial and α-glucosidase inhibition potential of methanol and 80% methanol extracts of three brown algae species, Polycladia myrica, Padina antillarum, and Sargassum boveanum, and a red alga, Palisada perforata, from the Persian Gulf coasts. Methods: Antibacterial activity of the algal extracts was assessed by broth dilution method against three gram-negative and -positive bacteria, including Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa; Staphylococcus epidermidis, Staphylococcus aureus, and Bacillus subtilis, respectively. Furthermore, the yeast’s α-glucosidase inhibition of the algal extracts was measured via colorimetric assay. In addition, we investigated the beneficial effect of 80% MeOH extract of S. boveanum on the blood glucose levels in streptozotocin-induced diabetic rats. Results: The MeOH extract of S. boveanum was the best antibacterial extract with MIC = 2.5 mg/mL against all bacterial strains except for E. coli. The MeOH and 80% MeOH extracts of P. myrica and P. antillarum inhibited α-glucosidase at most with IC50 values of 12.70 ± 1.88 µg/mL and 13.06 ± 4.44 µg/mL, respectively. The oral gavage of S. boveanum extract in streptozotocin- (STZ-) induced diabetic rats resulted in decreasing their postprandial blood glucose levels. The algae and acarbose decreased blood glucose levels after sucrose administration in 60 minutes, compared to the non-drug-treated animals, with p values of 0.03 and 0.007, respectively. Conclusions: Overall, due to the in vitro and in vivo antidiabetic potential of S. boveanum, we suggest the alga as a new source for the isolation and identification of potential antidiabetic and antibacterial compounds. | en |
| DOI | https://doi.org/10.5812/ijpr-133731 | en |
| Keyword | Algae | en |
| Keyword | Antibacterial | en |
| Keyword | Blood Glucose Level | en |
| Keyword | STZ-induced Diabetic Rats | en |
| Publisher | Brieflands | en |
| Title | In Vitro and In Vivo Antidiabetic, α-Glucosidase Inhibition and Antibacterial Activities of Three Brown Algae, <i>Polycladia myrica</i>, <i>Padina antillarum</i>, and <i>Sargassum boveanum</i>, and a Red Alga, <i>Palisada perforata</i> from the Persian Gulf | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- ijpr-22-1-133731.pdf
- Size:
- 630.79 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF