Effect of vitamins B<sub>1</sub>, B<sub>6,</sub> and B<sub>12</sub> (Neurobion) on Diisopropylfluorophosphate–induced Delayed Neuropathy in Mice

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AuthorMohsen Ebrahimien
AuthorMohammad Javad Khoushnouden
AuthorMajid Zia-Behbahanien
Issued Date2018-07-31en
AbstractCertain organophosphorus esters, such as diisopropylfluorophosphate (DFP), cause delayed neuropathy by inhibition of neuropathy target esterase (NTE) keeping the neuron in normal function. In this study, effects of neurobion alone and in combination with dexamethasone on DFP–induced delayed neuropathy were evaluated. Thirty-five mice were divided into five groups, each consisting of 7 mice. Except group1 (Normal group), group 2 received normal saline and 1h later, 1 mg/kg DFP; groups 3, 4 and 5 received 150 mg/kg neurobion, 2 mg/kg dexamethasone and 150 mg/kg neurobion plus 2 mg/kg dexamethasone, respectively and 1h later 1mg/kg DFP. Twenty one days after the last injection, the mice were killed by decapitation under deep anesthesia. NTE level was determined in the brain and though there was no significant difference between the groups, neurobion and neurobion plus dexamethasone partly- not significantly (p > 0.05)- were able to prevent reduction of NTE in the brain caused by DFP. Histopathological evaluation of sciatic nerves showed that neurobion and neurobion plus dexamethasone significantly suppressed the harmful effect of DFP.en
DOIhttps://doi.org/10.22037/ijpr.2018.2256en
KeywordOrganophosphorus compounden
KeywordDFPen
KeywordDelayed neuropathyen
KeywordNeuropathy target esteraseen
KeywordNeurobionen
PublisherBrieflandsen
TitleEffect of vitamins B<sub>1</sub>, B<sub>6,</sub> and B<sub>12</sub> (Neurobion) on Diisopropylfluorophosphate–induced Delayed Neuropathy in Miceen
TypeOriginal Articleen

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