The evaluation of HLA class II association With allergic asthma

Abstract

Major histocompatibility complex (MHC)‚ which plays a major biological function in immune response is generally associated with so many human diseases. During recent years a strong relationship between allergic diseases and HLA antigens have been demonstrated. This study was done to investigate the relationship between allergic asthma and HLA antigens in Iranian’s atopic asthmatic patients. This case control study was done on 30 atopic asthmatic patients and healthy controls in 1376 in Tehran. Human leukocyte antigen (HLA) typing was performed by standard N.I.H procedures and the results analyzed. The results of this study showed that there is a significant relation between allergic asthma and some of class II HLA antigens i.e: frequency of DR2 and DR53 antigen in patient group in comparison with healthy group has been increased and frequency of DR5, DR11, DR52 and DQ1 has been decreased.