Zahedan Journal of Research in Medical Sciences

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The Zahedan Journal of Research in Medical Sciences (ZJRMS) Journal is the official scientific quarterly publication of the Zahedan University of Medical Sciences (ZAUMS). ZJRMS is a peer-reviewed journal fostering the integration of medical sciences with traditionally health-related issues in the English language. All individuals have free access to PDF and XML formats of all archived issues. The editorial office does not receive article submission processing or publication fees from the authors or authors’ institutions. The open access policy of the journal aims at increasing the visibility and accessibility of the published content of the articles and providing a desirable research impact.

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Now showing 1 - 20 of 1733

Recent Progress in Nanoparticle-Driven Drug Delivery Strategies for Cancer Therapy: Focus on Colorectal Cancer
(Brieflands, 2025-01-31) Mohammad Kordkatouli; Mehrali Mahmoodjanloo; Aryan Sateei; Mir Mohammad Hossein Mousavi; Audrius Dulskas
Context: Nanotechnology, specifically nanoparticles, has revolutionized cancer therapy through enhanced drug delivery, precise imaging, and accurate diagnosis. Their ability to target cancer cells directly with minimal side effects makes them especially promising for treating colorectal cancer (CRC), allowing for more effective treatments. Methods: A systematic literature review was conducted across multiple databases (PubMed, Scopus, Embase, Cochrane, Web of Science, Google Scholar) using MeSH terms such as nanoparticles, cancer, drug delivery, and target cells. The objectives of this review were to examine the effectiveness of nanoparticle-based drug delivery systems, evaluate their targeting mechanisms, and assess their impact on treatment outcomes for CRC. Study eligibility, participant inclusion criteria, and specific intervention types were critically analyzed to ensure a comprehensive understanding. Results: Nanoparticle-based systems have demonstrated significant promise in shrinking tumors, improving drug accumulation at the tumor site, and facilitating easier surgical removal. These systems enhance drug efficacy, reduce toxicity, and overcome biological barriers in CRC, particularly through the use of pH-responsive and thermoresponsive nanoparticles. Conclusions: The application of nanoparticles for drug delivery represents a safe and effective treatment option, demonstrating improved targeting, reduced side effects, and enhanced therapeutic outcomes. However, further research is necessary to evaluate the long-term safety, efficacy, and scalability of these systems, alongside their optimization for clinical use in personalized treatments.
Assessing of the Anxiety Level of COVID-19 and Its Relationship with the Demographic Variables of Pregnant Women: A Cross-Sectional Study
(Brieflands, 2025-01-31) Samaneh Tahmasebi Ghorabi; Arian Karimi Rouzbahani; Masoumeh Ghafarzadeh; Mojgan Kaviani; Banafsheh Derikvand; Azin Niazi; Fatemeh Yari
Background: The current and alarming situation of the COVID-19 pandemic may cause anxiety in pregnant women. Objectives: Given the importance of both physical and mental health for expectant women, this study investigated COVID-19 anxiety among pregnant women referred to Asalian Hospital in Khorramabad during 2021 - 2022. Methods: This descriptive cross-sectional study was conducted among pregnant women referred to Asalian Hospital in Khorramabad. A total of 253 pregnant women were included in the study based on the study criteria and the available sampling method. The Corona Virus Anxiety Scale was used to collect data through a questionnaire. The data were analyzed using SPSS version 22, and analysis of variance (ANOVA) and t-tests were employed to examine the data, with the significance level set at 0.05. Results: The mean age of expectant women was 27.7 ± 3.56 years. The average anxiety score among the pregnant women was 4.39 ± 3.99, with physical and mental dimension scores of 1.67 ± 1.89 and 2.71 ± 2.15, respectively. There was a statistically significant difference in the average anxiety scores related to COVID-19 based on education, place of residence, and the number of pregnancies (P < 0.05). Conclusions: The present study found that pregnant women experienced a low level of anxiety in response to COVID-19. The average score for the psychological aspect of COVID-19-related anxiety among these women was greater than that for the physical aspect. Therefore, by increasing public awareness about COVID-19 and providing positive psychological programs in the media aimed at managing stress, anxiety in pregnant women can be effectively reduced.
Investigating The Synergistic and Antimicrobial Effect of Glycolipid Biosurfactants Produced by Shewanella alga 12B and Bacillus pumilus SG Bacteria with Thyme Plant Extract on Some Pathogenic Bacteria
(Brieflands, 2024-10-31) Arezou Rezaee; Fatemeh Bazzi Allahri; Pooya Samian; Seyed Mostafa Ghasemi Najarkolaee; Reza Yusofvand; Tahereh Eslam-Manesh; Mehdi Hassanshahi
Background: Thyme is widely recognized for its antimicrobial properties, attributed to the effective compounds present in its extract that inhibit and destroy pathogenic bacteria. Objectives: This study explores the impact of combining thyme extract with biosurfactants on pathogenic bacteria and biofilm. The biosurfactants 12B and SG have inherent antimicrobial effects, and their combination with thyme extract demonstrated synergistic effects. Methods: The experiments involved preparing methanolic thyme extract in combination with biosurfactants 12B and SG. Disk diffusion and well diffusion tests were conducted to assess the antimicrobial activity of this combination. The inhibition zones for Acinetobacterbaumannii, Bacilluscereus, Escherichiacoli, and methicillin-resistant Staphylococcusaureus (MRSA) were measured. Further tests determined the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) for these bacteria. To evaluate synergistic effects, the fractional inhibitory concentration (FIC) and fractional inhibitory concentration index (FICI) were calculated. Results: The anti-biofilm effects of the biosurfactants combined with thyme extract were analyzed by testing biofilm formation inhibition, biofilm destruction, and inhibition of dehydrogenase enzyme activity within the biofilm. Biofilm assays were conducted using microplates, with readings taken at 490 nm using an ELISA reader. Conclusions: The biofilm tests demonstrated the effectiveness of thyme extract combined with biosurfactants. The results indicated that this combination exhibits antibacterial, anti-biofilm, and synergistic effects, making it effective against both antibiotic-resistant and non-resistant pathogenic bacteria.
Assessing four different methods of taper on athletes hematological responses
(Brieflands, 2004-03-31) AR Asgari Ashtiani; Mehdi Mohammadi; Ramin Saravani; Mohsen Taheri
Background: In serious competitions in order to keep the acquired fitness, athletes are advised to reduce the exercise intensity before starting the races. This technique is called taper. The purpose of this study was to compare four usual procedures of Taper and effect of them on the Hematological responses by measuring Vo2 max, hematological and biochemical factors. Methods and materials: Sixty semi professional athletes, 20 to 35 years old with Vo2 max between 30-45 three milts/kg/min were selected. Exercises were in three stages and took for eight weeks. In the first stage, which lastd for 4 weeks athletes did moderate intensity exercise three days a week and 30 minutes a day. Second stage started after the first stage with vigorous exercise three days a week and 45 minutes a day that lasted for two weeks. In the third stage taper, the subjects were randomly divided into four groups. The program of the first group was two days week and exercise intensity so was done with 85%, 75%, 65% and 55% of maximum exercise intensity. Second group program was two days a week exercise with 50% of maximum exercise intensity. The third group program was two days a week exercise with gradual reduction of exercise intensity. The fourth group had only rest. At second and sixth weeks after doing progressive exercise and taper, blood samples were taken from the cases and were sent to a reliable diagnosis lab. Results: Collected data from different taper methods were analyzed using repeated measures ANOVA and no significant difference between biochemical factors (P>0.05) was seen but the data showed a significant difference among Vo2 max values after using theses methods (P=0.04). In addition, there was significant difference in hemoglobin, hematocrit, M.C.H, M.V.C, platelets, W.B.C and Vo2 max when measured in second week, sixth week and later on Taper (P
Epidemiologic survey of documented measles outbreak in Tehran
(Brieflands, 2004-06-30) 1 Mokhtari; M Alavi Moghaddam; D Yadegari; Masoud Salehi; F Shahim; Iraj Zareban
Background: In spite of extended vaccination programs against measles, it is the most preventive contagious disease that leads to death. For adaptation of WHO policy for measles in Iran; we should determine susceptible age population whom at present lay out of current vaccination program . Methods and Materials: In this descriptive study which was performed in the public health School of the Tehran medical university ; we obtained 131 documented measles cases among 650 suspected case of measles ( as WHO discrimination ) According to serum samples analysis ( capture IgM EIA 71% and 29 % HI ). Results: In this study 63. 4 % of cases were male and 39.6 % were females. Between patients, the most prevalent age group was between 15 - 19 years old. Two peaks of the time of the disease were March and June. History of past vaccination against measles showed that 43 % had unknown history; 24. 4 % had two vaccination; 39. 3 % had one vaccination and 3.1 % had no vaccination history. Conclusions: It is suggested (by further investigations in future) the need for revaccination of measles for age group of 15-19 in Iran will be determined
Effect of subcutaneous injection of morphine on activity of neurons in the nucleus cuneiformis of rat
(Brieflands, 2008-12-31) Abbas Haghparast; AmirMohammad Alizadeh; Fereshteh Motamedi
Background: The similarities between periaqueductal gray matter and the nucleus cuneiformis in both ultrastructural and functional levels suggest that this nucleus may play an important role in the morphine-induced analgesia. This study was designed to determine neuronal activity and responsiveness to peripheral morphine administration in the nucleus coneiformis of rat. Materials and Methods: In this study, neural activity of cuneiform neurons in response to peripheral administration of morphine was recorded by extracellular single unit recording technique. Firing rate of neurons was recorded in four groups: intact group (n=19) to determine the spontaneous (baseline) activity, saline group (n=20), morphine group (n=39) and morphine + naloxone group (n=12), before and after drug administration. Results: Our findings showed that the firing rate in majority of cuneiform neurons decreased after morphine (3.8 mg/kg; SC) administration. Activity of neurons (n=39) in the cuneiform neurons was reduced significantly (P
Anatomical and Morphological Features of Root Canal in
(Brieflands, 2008-12-31) Eshagh Ali Saberi; Mohsen Noormandi poor; Mohsen Hosseini-Goosheh; Ali Salarimoghadam
Background: Many teeth that are affected with irreversible pulpal lesions can remain with endodontic treatment and keep their function in dental system for years. The most important factor in endodontic therapy is related to chemical and mechanical preparation. Since the most unsuccessful endodontic therapy in mandibular incisor results from unclean root canal, especially the lingual canal, so we performed this study to determine the anatomical and morphological features of root canal in mandibular incisors.
The Association between Cigarette Smoking and Acne Intensity
(Brieflands, 2009-09-30) Ramin Taheri; Mohammad Nasaji; Raheb Ghorbani; Zahra Mohmmadi
Background: Acne vulgaris is a common chronic inflammatory disease of pilosebaceous unit. Different factors have been suggested to influence acne including diet, menstruation and occupation. The role of some of these factors on acne intensity is confirmed. The affect of Cigarette smoking on acne intensity has been suggested. In this research, we evaluated the association between cigarette smoking and the acne intensity. Materials and Methods: This cross-sectional study was performed on 278 smoker and 277non smoker males referred to dermatology clinics of Semnan during 2006-2007. The dermatologists interviewing the patients completed questionnaires based on clinical diagnosis and intensity of acne. Data analysis was performed using t-test, Mann-Whitney, Chi-square and Spearman coefficient tests. P-value less than 0.05 were considered significant. Results: Severe acne was observed in 16.6% of non-smokers and 22.7% of smokers. Distribution of acne intensity in both groups was significant (P=0.023). Association between duration of cigarette smoking and acne intensity was significant too (P
Alternative Medicine
(Brieflands, 2011-03-31) fateme adelinejhad
This article has no abstract.
The effect of melatonin and luzindole on spatial learning and memory in rats treated with darkness
(Brieflands, 2011-03-31) Mahmoud Salami; Gholamali Hamidi; S. Alireza Talaei-Zavareh
Background : During critical periods of growth, evolution dependent of sensory experience has a deep effect on the formation and proper function of mammal’s CNS. The aim of this study is to assess the interaction of melatonin and its antagonist, luzindole on rat’s spatial learning and memory processes treated in darkness using the Morris Water Maze (MWM).
Protective and antioxidant activities of turnip root ethanolic extract against cisplatin induced hepatotoxicity in rats
(Brieflands, 2012-02-28) Daryoush Mohajeri; Yousef Doustar; Ghafour Mousavi
Background: Cisplatin is an antineoplastic drug and at high doses is hepatotoxic. Oxidative stress has been proven to be involved in cisplatin-induced hepatotoxicity. Because of antioxidant potential of turnip (Brassica rapa. L) root, the objective of this study was to examine the protective effect of turnip root ethanolic extract (TREE), on cisplatin-induced hepatotoxicity in rat.
The Effect of Cognitive-Behavioral Therapy (CBT) on Reduction of Psychological Symptoms among Patients with Cancer
(Brieflands, 2012-04-30) Farhad Kahrazei; Esmat Danesh; Alireza Hydarzadegan
Background: The objective of this study was to investigate the effect of cognitive-behavioral therapy (CBT) on the psychological symptoms among patients with cancer.
Effect of Helicobacter Pylori Treatment on the Number and Severity of Migraine Attacks
(Brieflands, 2012-08-31) Alireza Bakhshipour; Mahsa Momeni; Nourollah ramroodi
Background: Migraine is a common headache with an unknown cause. Migraine is about three times more common in women (18.2%) than in men (6.2%). The recent studies have posed the possible relationship between the Helicobacter pylori infection and migraine headache. This study tries to analyze the effect of treating H. pylori infection on number and severity of migraine attacks.Materials and Methods: In this clinical pilot study, a number of 60 patients with migraine were examined in terms of infecting with H. pylori. Patients with the infections were treated by H. pylori eradication standard triple regimen and the frequency and severity of their migraine attacks were measured for three months and finally the average of frequency and severity of attacks before and after treatment were compared.Results: The average frequency of the migraine attacks in patients with the H.pylori infection who have been treated was 7.1 before treatment and 2.7 after treatment (p=0.001). Likewise, the severity rate of such attacks in such patients was 9 which decreased to 4.5 after treatment (p=0.002).Conclusion: According to our study, patients with migraine attacks are preferred to be tested in terms of infecting with H. pylori, and eradication of this infection can be effective in decreasing of the migraine attacks.
The Diagnostic Agreement of Original and Faxed Copies of Electrocardiograms
(Brieflands, 2013-02-28) Sadrihe Hajesmaeel-Gohari; Mahdieh Hajimohammadhasani-Ravari; Maryam Ghasemzadeh-Kahnooei; Farhad Asadi; Kambiz Bahaadinbeigy
Coeliac in Patients with Gastrointestinal Symptoms: A Population-Based Study in Tehran
(Brieflands, 2013-02-28) Mohammad Rostami-Nejad; Zahra Nochi; Mohamad Amin Pourhoseingholi; Kamran Rostami; Shohreh Almasi; Farahnaz Jabari; Parvaneh Mohamadi; Mona Rajaeefar; Mahsa Khani-Yaghma; Mohammad Reza Zali
Validating and Investigating Reliability of Comprehensive Feeding Practices Questionnaire
(Brieflands, 2013-03-31) Saeid Doaei; Naser Kalantari; Maryam Gholamalizadeh; Bahram Rashidkhani
Background : The present research aims to validate and discuss the reliability of Comprehensive Feeding Practices Questionnaire (CFPQ).Materials and Methods : In this cross-sectional study, 150 mothers with 3-6 year old children in the city of Rasht were selected through cluster random sampling from the public and private kindergartens in 2010. After being confident about the translation validity, the degree of validation (content and structure) and validity (test-retest reliability and internal consistency) of the questionnaire was examined.Results : The degree of validation of questionnaire content, except questions 2, 16 and 46, was at a high level and these three questions were omitted. The method of the consistency of factors and total scores of the questionnaire was used to study the validation of structure, which was satisfactory and varied between 0.30-0.72. The validity of questionnaire was examined through test-retest and Cronbach's alpha methods. The Intraclass Correlation Coefficient (ICC) was between 0.80-0.91 and Cronbach's alpha was between 0.80-0.90.Conclusion : In general, the Comprehensive Feeding Practices Questionnaire (CFPQ) was proved to be valid and with respect to the results obtained from the present research, it can be used in the research on child diet.
Hemoptysis Caused by Leech Infestation: A Unique Case
(Brieflands, 2013-04-30) Latif Moini; Tahmineh Farbod-Ara
Chronic Urticaria: The Necessity of Laboratory Examination
(Brieflands, 2013-04-30) Javad Ghaffari; Mohammad Khademloo; Iraj Mohammadzadeh; Masoud Golpoor
The Comparison of Pain Relief between Postoperative Wound Infiltration with Bupivacaine 0.5% Combined with Epinephrine after Elective Cesarean Section
(Brieflands, 2013-04-30) vida modarres nejad; batool Motamedi; Mazyar Nafisy
Background : So many methods have been developed and tested to control post-surgical pain. In this study, the effect of bupivacaine-H medicine (along with epinephrine) on the post-surgical pain reduction in cesarean mothers was examined.Materials and Method s: In a double blind randomized clinical trial study conducted in Kerman, 70 pregnant women who were eligible for elective cesarean section participated in the study as randomized into two case and control groups. In all the patients, cesarean section incision lengths were equal and bupivacaine was injected after infant delivery. In the control group, physiological serum was used as placebo instead of medicine. Pain severity was compared between two groups using Visual Analogue Scale (VAS) on 6, 12, 24 and 48 hours after operation. The results were analyzed applying SPSS-11 software and using Mann-Whitney U and Wilcoxon tests.Results : Mean age of the patients was 25.36 years with standard aviation of 2.48 years and the age range of 18-28 years. A previous cesarean with relative frequency of 38.5 percent was the main cause of cesarean section in such patients. In the case group, pain severity before 24 hours was less than that in the control group. After 24 hours of the operation, the pain severity in both case and control groups were similar.Conclusion : In general, bupivacaine injection into the cesarean incision area will cause to reduce the pain after cesarean section in the mothers and considering its minor complications, such medicine may be used as an effective pain control method in women.
Frequency of Congenital Structural Anomalies in Newborns of Shahroud, Iran
(Brieflands, 2013-09-30) Katayoon Vakilian; Sepideh Hajian; Afsaneh Sadghian
This article has no abstract.

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