Time-dependent frailty model to gap times between recurrent events with application to epilepsy data
| Author | Samaneh Hossainzadeh | en |
| Author | Soghrat Faghihzadeh | en |
| Author | Mehdi Rahgozar | en |
| Author | Ebrahim Hajizadeh | en |
| Author | Seyed Sohrab Hashemi Fesharaki | en |
| Author | Marzieh Gharakhani | en |
| Orcid | Samaneh Hossainzadeh [0000-0003-0559-148X] | en |
| Issued Date | 2016-06-30 | en |
| Abstract | Introduction: In recurrent event a specific event occur repeatedly over time for a person. The frailty models take into account this correlation and provide efficient inferences. The frailties are assumed to be constant over time that it may be insufficient. Therefore time-varying frailty models are more realistic models. The aim of this study was to fit a time-dependent frailty model in the gap time between recurrent events. Materials and methods: In this study, a time-dependent frailty model was introduced in the gap time between recurrent events, that was a generalization of the Wintrebert (2004) model in cluster data (center-effect). The parameters were estimated by Gaussian quadrature method. The model was applied to epilepsy data. Results: The time-dependent frailty model fitted better in compare to shared frailty model. The observation time for IED on EEG in 56 patients (%73 male, %34 veteran status) with epilepsy was studied. Age and veteran status were the two risk factors in the gap time between IEDs. Variance of frailty was significant too. Conclusion: The result of time-dependent frailty model was reliable when there were unknown time-dependent factors in medical data and make changes on times of occurring recurrent events. The Gaussian quadrature was an applied method to fit a time-dependent frailty model. The programming for this method was comfortable hence this method can cause time-dependent fraility models to be more practical in medical studies. | en |
| DOI | https://doi.org/ | en |
| Keyword | Time-Dependent Frailty | en |
| Keyword | Recurrent Event | en |
| Keyword | Gaussian Quadrature | en |
| Keyword | Epilepsy | en |
| Keyword | شکنندگی وابسته به زمان | en |
| Keyword | حوادث بازگشتی | en |
| Keyword | مربعبندی گاوسی | en |
| Keyword | صرع. | en |
| Publisher | Brieflands | en |
| Title | Time-dependent frailty model to gap times between recurrent events with application to epilepsy data | en |
| Type | Research Article | en |
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