Interpretation of Tongue Squamous Cell Carcinoma via Protein-Protein Interaction Network Construction and Analysis
| Author | Mona Zamanian Azodi |
| Author | Mostafa Rezaei-Tavirani |
| Author | Majid Rezaei-Tavirani |
| Author | Vahid Mansouri |
| Author | Reza Vafaee |
| Issued Date | 2018-01-31 |
| Abstract | Background: Tongue squamous cell carcinoma is one of the prominent cancers in the oral cavity. Molecular investigations based on interaction analysis can be promising towards providing a better resolution of malignant neoplasms. Here, the protein-protein interaction network of tongue cancer is studied. Methods: The protein-protein interaction network was constructed by the application of Cytoscape 3.5.1 and the related algorithms. Centrality analysis via the degree, betweenness, and closeness centralities was conducted. Results: The result indicated that there are seven chief proteins in the network foundation. Moreover, enrichment evaluation suggested two associated biological processes including Response to UV-A, Response to interlukin-7, cellular response to alcohol, and catenin import into nucleus process using CluePedia. Conclusions: It can be concluded that the identified central panel proteins and their related biological processes can shed light on the neoplasm mechanisms and are worth pursuing for clinical approaches. |
| DOI | https://doi.org/10.5812/ijcm.62004 |
| Keyword | Tongue Squamous Cell Carcinoma |
| Keyword | Protein-Protein Interaction Network Analysis |
| Keyword | Gene Ontology |
| Keyword | Biological Process |
| Keyword | Topological Analysis |
| Publisher | Brieflands |
| Title | Interpretation of Tongue Squamous Cell Carcinoma via Protein-Protein Interaction Network Construction and Analysis |
| Type | Research Article |