Interpretation of Tongue Squamous Cell Carcinoma via Protein-Protein Interaction Network Construction and Analysis

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AuthorMona Zamanian Azodien
AuthorMostafa Rezaei-Taviranien
AuthorMajid Rezaei-Taviranien
AuthorVahid Mansourien
AuthorReza Vafaeeen
OrcidMona Zamanian Azodi [0000-0003-1894-5021]en
OrcidMostafa Rezaei-Tavirani [0000-0003-1767-7475]en
OrcidMajid Rezaei-Tavirani [0000-0003-1767-7475]en
Issued Date2018-01-31en
AbstractBackground: Tongue squamous cell carcinoma is one of the prominent cancers in the oral cavity. Molecular investigations based on interaction analysis can be promising towards providing a better resolution of malignant neoplasms. Here, the protein-protein interaction network of tongue cancer is studied. Methods: The protein-protein interaction network was constructed by the application of Cytoscape 3.5.1 and the related algorithms. Centrality analysis via the degree, betweenness, and closeness centralities was conducted. Results: The result indicated that there are seven chief proteins in the network foundation. Moreover, enrichment evaluation suggested two associated biological processes including Response to UV-A, Response to interlukin-7, cellular response to alcohol, and catenin import into nucleus process using CluePedia. Conclusions: It can be concluded that the identified central panel proteins and their related biological processes can shed light on the neoplasm mechanisms and are worth pursuing for clinical approaches.en
DOIhttps://doi.org/10.5812/ijcm.62004en
KeywordTongue Squamous Cell Carcinomaen
KeywordProtein-Protein Interaction Network Analysisen
KeywordGene Ontologyen
KeywordBiological Processen
KeywordTopological Analysisen
PublisherBrieflandsen
TitleInterpretation of Tongue Squamous Cell Carcinoma via Protein-Protein Interaction Network Construction and Analysisen
TypeResearch Articleen

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International Journal of Cancer Management