Estimation of Seroprevalence of Anti-Herpes Simplex Virus Type-1 IgG Among Healthy Blood Donors in Sakaka City, Aljouf, Saudi Arabia
| Author | Ahmed E. Taha | en |
| Author | Amany A. Ghazy | en |
| Author | Abdulrahman Almaeen | en |
| Author | Ibrahim Taher | en |
| Author | Tarek El-Metwally | en |
| Author | Mohammad Ahmad Alayyaf | en |
| Author | Fahad Alrayes | en |
| Author | Ahmed Alinad | en |
| Author | Saqer Albulayhid | en |
| Author | Abdulrahman Aldakhil | en |
| Orcid | Ahmed E. Taha [0000-0002-5766-4495] | en |
| Orcid | Amany A. Ghazy [0000-0002-5603-1303] | en |
| Orcid | Abdulrahman Almaeen [0000-0001-9267-2637] | en |
| Orcid | Ibrahim Taher [0000-0003-2790-6972] | en |
| Orcid | Tarek El-Metwally [0000-0001-9040-6642] | en |
| Orcid | Mohammad Ahmad Alayyaf [0000-0002-3674-5720] | en |
| Issued Date | 2023-07-31 | en |
| Abstract | Background: Herpes simplex virus type-1 (HSV-1) is a highly infectious neurotropic virus. The data on HSV-1 infection in Saudi Arabia, including the seroprevalence of HSV-1 antibodies, are scarce. Objectives: This is the first study to evaluate the prevalence of anti-HSV-1 immunoglobulin G (IgG) in donated blood in Sakaka, Aljouf, Saudi Arabia. Methods: A total of 300 donated blood samples were collected from the Blood Bank of Prince Mutaib Bin Abdulaziz Hospital in Sakaka. Sensitive and specific enzyme-linked immunosorbent assay (ELISA) was used to detect anti-HSV-1 IgG. A comparison of the age, gender, education, occupation, income, hand hygiene, travel history, and cupping practice of blood donors stratified for the extent of anti-HSV-1 IgG was made. Results: There was a low prevalence of anti-HSV-1 IgG (20%; n = 60/300). Moreover, 50.0% of IgG-positive participants were in the age group of 41 - 45 years, and 81.7% of the participants had a household income of < 10000 SAR (statistically highly significant; P < 0.001*). All the participants performed hand washing with soap before handling food and after using the toilet. Furthermore, IgG-positive participants had a bachelor’s degree (50.0%), were governmental employees (60.0%), were international travelers (50.0%), and practiced cupping (50.0%) with statistically significant associations (P < 0.05*). Conclusions: The current study’s findings support previous reports about the key importance of improving socioeconomic conditions and hygiene measures in reducing the spread of HSV-1. The present study provides an alarm regarding reaching the age of sexual debut without acquiring protective anti-HSV-1 immunoglobulins, consequently becoming more susceptible to acquiring HSV-1 infection through the genital route. These data support the urgent need to develop an effective anti-HSV-1 vaccine. | en |
| DOI | https://doi.org/10.5812/jjm-136606 | en |
| Keyword | Anti-HSV-1 IgG | en |
| Keyword | Blood Transfusion | en |
| Keyword | HSV-1 | en |
| Keyword | Prevention | en |
| Keyword | Transmission | en |
| Keyword | Vaccine | en |
| Publisher | Brieflands | en |
| Title | Estimation of Seroprevalence of Anti-Herpes Simplex Virus Type-1 IgG Among Healthy Blood Donors in Sakaka City, Aljouf, Saudi Arabia | en |
| Type | Research Article | en |
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