Effects of saffron extract on sperm parameters in rats with experimentally induced varicocele

Simple item page
AuthorF Amidien
AuthorS Ebrahimien
AuthorM Abbasien
AuthorM yazdanien
AuthorS Ghasemien
Issued Date2014-12-16en
Abstract  Background: Varicocele is the most common cause of infertility in men. Increased release of free oxygen radicals is one of the most important mechanisms of damage in the pathophysiology of varicocele.   Objective: The aim of this study was to determine the effects of saffron extract treatment on sperm parameters (sperm count, motility and morphology) in rats with experimentally induced varicocele .   Methods: In this experimental study, 24 male Wistar rats were randomly divided into four groups: varicocele without treatment, sham, control, varicocele with treatment. Varicocele was induced in both varicocele groups. Saffron ethanolic extract (50 mg/kg) was daily administered intraperitoneally in the varicocele group with treatment for eight weeks. After eight weeks, the sperm parameters were studied in all groups. Data were analyzed using one way ANOVA.   Findings: All sperm parameters in the varicocele groups were significantly reduced in comparison to the control group. The sperm parameters were significantly improved by saffron ethanolic extract.   Conclusion: With regards to the results, crocin and safranal in saffron extract which probably eliminate free radicals can be effective in treatment of infertility caused by varicocele.       en
DOIhttps://doi.org/en
KeywordVaricoceleen
KeywordSpermatozoaen
KeywordSperm Counten
KeywordSperm Motilityen
KeywordFertilityen
PublisherBrieflandsen
TitleEffects of saffron extract on sperm parameters in rats with experimentally induced varicoceleen
TypeResearch Articleen

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
article-1-1579-en.pdf.pdf
Size:
186.03 KB
Format:
Adobe Portable Document Format
Description:
Article/s PDF
Download

Collections

Journal of Inflammatory Diseases