Protective Effect of Vitamin E on Formaldehyde-Induced Injuries in the Rat Kidney
| Author | Masoumeh Faghani | en |
| Author | Yeganezahra Kohestani | en |
| Author | Ebrahim Nasiri | en |
| Author | Hassan Moladoust | en |
| Author | Mojgan Mesbah | en |
| Issued Date | 2014-10-01 | en |
| Abstract | Background: Formaldehyde (F) is a chemical component that has an extensive usage on fixation of tissues and produces different types of reactive oxygen species (ROS) in our body. Studies have shown that long exposure to F damages the eyes, nose and throat; in addition it has adverse effects on body organs such as the urinary system. Vitamins can reduce free ROS. Objectives: The aim of this study was evaluating the protective effect of vitamin E on the kidney damaged by formaldehyde. Materials and Methods: Male adult wistar rats were divided into three groups. Group A (control): rats received vehicle (normal saline) for two weeks. Group E1 (formaldehyde): rats received formaldehyde (10 mg/kg) for two weeks. Group E2 (formaldehyde + vitamin E): rats received formaldehyde (10 mg/kg) and vitamin E (30 mg/kg) for two weeks. After two weeks, all rats were killed, and the kidneys were dissected and processed for routine histological staining. Results: Comparison of the control and formaldehyde groups with the vitamin E group revealed that there were significant differences in lumen size and nuclear color of proximal tubules in rats treated by vitamin E (P < 0.05). Cell degeneration, lumen size, number and size of nucleus of distal tubules were statistically different among the three groups. In the vitamin E treated group observed histological changes were improved compared to the formaldehyde group. Conclusions: According to the results of this study, vitamin E probably improves the harmful effects of formaldehyde on rat kidney tissue. | en |
| DOI | https://doi.org/10.17795/gct-21539 | en |
| Keyword | Formaldehyde | en |
| Keyword | kidney | en |
| Keyword | Vitamin E | en |
| Keyword | rat | en |
| Keyword | histology | en |
| Keyword | injuries | en |
| Publisher | Brieflands | en |
| Title | Protective Effect of Vitamin E on Formaldehyde-Induced Injuries in the Rat Kidney | en |
| Type | Research Article | en |
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