Ephedrine Versus Ondansetron in the Prevention of Hypotension During Cesarean Section: A Randomized, Double Blind, Placebo-Controlled Trial: Spinal induced hypotension in parturients
| Author | Ahmed Mohamed Khamis | en |
| Author | Abd El-Aziz A. Abd El-Aziz | en |
| Author | Raham Hasan Mostafa | en |
| Author | Mohamed Abdallah Noser | en |
| Orcid | Raham Hasan Mostafa [0000-0002-5560-2733] | en |
| Issued Date | 2022-09-30 | en |
| Abstract | Background: Common side effects of spinal anesthesia for cesarean section (CS) include hypotension and bradycardia. Ondansetron, a 5HT3 receptor antagonist has been suggested for prophylactic prevention of spinal?induced hypotension (SIH) in elective cesarean section. Objective: This study was conducted to compare a traditional vasopressor ?ephedrine? with two different doses of 5-HT3 receptor antagonist ?ondansetron? in preventing SIH during cesarean section. Patients: A total of 168 full?term parturients undergoing CS under spinal anesthesia were included. Interventions: Patients were divided randomly into 4 groups (ephedrine, 4 mg ondansetron (O4), 8 mg ondansetron (O8) and control group). All patients were monitored for mean blood pressure, heart rate, vasopressor requirement, and side effects. Main outcome measure: The primary outcome of this study was the incidence of SIH in all 4 groups during the first 60 minutes after spinal anesthesia Results: The incidence of SIH was significantly higher in the control group (45,2%) when compared to ephedrine, O4, O8 groups (19%, 16.7%, 11.9% respectively). There were significant differences between the 4 groups regarding maternal mean arterial pressures during the 1st 60 minutes after spinal anesthesia. No side effects were recorded. Conclusion: Prophylactic intravenous ondansetron - at a dose of 4mg or 8mg- could be an effective alternative to ephedrine in reducing the incidence of SIH and requirement of vasopressors in parturients undergoing CS. | en |
| DOI | https://doi.org/10.22037/jcma.v7i3.37841 | en |
| Keyword | Bezold?Jarisch reflex | en |
| Keyword | cesarean section | en |
| Keyword | ephedrine | en |
| Keyword | ondansetron | en |
| Keyword | spinal induced hypotension | en |
| Publisher | Brieflands | en |
| Title | Ephedrine Versus Ondansetron in the Prevention of Hypotension During Cesarean Section: A Randomized, Double Blind, Placebo-Controlled Trial: Spinal induced hypotension in parturients | en |
| Type | Original Articles | en |
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