Synthesis of N-arylmethyl Substituted Indole Derivatives as New Antiplatelet Aggregation Agents
| Author | Masoud Faghih Akhlaghi | en |
| Author | Salimeh Amidi | en |
| Author | Marjan Esfahanizadeh | en |
| Author | Marjan Daeihamed | en |
| Author | Farzad Kobarfard | en |
| Issued Date | 2014-02-28 | en |
| Abstract | A number of N-arylmethyl substituted indole derivatives have been synthesized and their effectiveness against ADP and arachidonic acid induced platelet aggregation in human plasma was determined. The desired compounds were synthesized by reacting the appropriate aniline derivative with isatin (or substituted isatin) to form the corresponding imine structures. The so formed compound was then activated using sodium hydride and reacted with the proper substituted benzyl halides. Among the tested compounds, derivatives 4a, 4c, 4d, 4f-i and 4k were the most potent compounds with satisfactory IC50 values (under 38.5 μM) for inhibition of platelet aggregation induced by arachidonic acid. | en |
| DOI | https://doi.org/10.22037/ijpr.2014.1456 | en |
| Keyword | 1-(substituted benzyl)-3-(phenylimino)indolin-2-one | en |
| Keyword | Antiplatelet | en |
| Keyword | Platelet aggregation | en |
| Keyword | N-arylmethyl indole | en |
| Publisher | Brieflands | en |
| Title | Synthesis of N-arylmethyl Substituted Indole Derivatives as New Antiplatelet Aggregation Agents | en |
| Type | Original Article | en |
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