Effectiveness of Absolute Ethanol Embolization-Sclerotherapy on Quality of Life in Patients with Peripheral Vascular Malformations: A Longitudinal Prospective Study
| Author | Lam Thao Cuong | en |
| Author | Ho Tat Bang | en |
| Orcid | Lam Thao Cuong [0000-0002-2935-9442] | en |
| Orcid | Ho Tat Bang [0000-0002-6786-1644] | en |
| Issued Date | 2026-06-30 | en |
| Abstract | Background: Peripheral vascular malformations, including venous malformations (VMs) and arteriovenous malformations (AVMs), are chronic conditions associated with pain, functional limitations, and impaired quality of life (QoL). Absolute ethanol embolization-sclerotherapy is a minimally invasive treatment option; however, prospective evidence regarding its effects on patient-reported QoL outcomes remains limited. Objectives: This study aimed to evaluate changes in QoL before and 6 months after absolute ethanol embolization-sclerotherapy in patients with peripheral vascular malformations and to assess overall treatment outcomes and procedure-related complications. Methods: This longitudinal prospective study was conducted at a tertiary referral university hospital in Ho Chi Minh City, Vietnam. Seventy-one adult patients aged ≥ 18 years with peripheral vascular malformations who underwent absolute ethanol embolization-sclerotherapy between July 2020 and June 2021 were included. Patients with VMs or AVMs underwent treatment based on clinical and imaging assessments. Quality of life was assessed using the SF-36 questionnaire before treatment and 6 months after intervention. Secondary outcomes included overall treatment outcomes and procedure-related complications during follow-up. Results: The study included 48 patients with VMs and 23 patients with AVMs. The mean age was 30.3 ± 9.0 years, and 67.6% of patients were female. In both the VM and AVM groups, all eight SF-36 domains and overall QoL scores improved significantly at 6 months compared with baseline (all P < 0.001). The greatest improvements were observed in role physical and bodily pain, whereas physical functioning showed the smallest change. Good to very good overall treatment outcomes were more frequent in the VM group than in the AVM group (93.8% vs. 60.9%). Postprocedural swelling occurred in all patients. Skin ulcers occurred in 25.0% of VM cases and 30.4% of AVM cases, and temporary nerve injury occurred in 12.5% and 8.7%, respectively. Deep vein thrombosis was recorded only in the VM group, whereas permanent nerve injury was observed only in the AVM group. Conclusions: Absolute ethanol embolization-sclerotherapy significantly improved QoL at 6 months in patients with peripheral vascular malformations, particularly by reducing pain and improving physical role functioning. Treatment outcomes were more favorable in patients with VMs than in those with AVMs, reflecting the greater complexity of AVM management. These findings support incorporating patient-reported QoL into posttreatment evaluation alongside clinical and imaging outcomes. | en |
| DOI | https://doi.org/10.5812/jnms-169891 | en |
| URI | https://brieflands.com/journals/jnms/articles/169891 | en |
| Keyword | Quality of Life | en |
| Keyword | Peripheral Vascular | en |
| Keyword | Malformations | en |
| Keyword | Ethanol | en |
| Keyword | Sclerotherapy | en |
| Publisher | Brieflands | en |
| Title | Effectiveness of Absolute Ethanol Embolization-Sclerotherapy on Quality of Life in Patients with Peripheral Vascular Malformations: A Longitudinal Prospective Study | en |
| Type | Research Article | en |
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