Frequency, Bacteriological Profile, and Outcome of Neonatal Sepsis with Carbapenem-Resistant Gram-Negative Bacteria at the Tertiary Neonatal Intensive Care Unit, Ahvaz, Iran
| Author | Seyyed Mohammad Hassan Aletayeb | en |
| Author | Masoud Dehdashtian | en |
| Author | Arash Malakian | en |
| Author | Mohammad Reza Aramesh | en |
| Author | Leila Kouti | en |
| Author | Fateme Aletayeb | en |
| Orcid | Seyyed Mohammad Hassan Aletayeb [0000-0001-6875-9230] | en |
| Orcid | Arash Malakian [0000-0003-0278-9167] | en |
| Orcid | Mohammad Reza Aramesh [0000-0003-3328-9691] | en |
| Orcid | Leila Kouti [0000-0002-5695-0596] | en |
| Issued Date | 2023-04-30 | en |
| Abstract | Background: One of the leading causes of neonatal mortality in low- and middle-income countries (LMICs) is neonatal sepsis caused by carbapenem-resistant gram-negative bacteria. Objectives: This study aimed to determine the frequency, bacterial profile, and outcome of carbapenem-resistant Gram-negative neonatal sepsis in southwest Iran. Methods: This 15-month retrospective cross-sectional descriptive study was conducted at a level 3 referral training hospital. The study included all neonates hospitalized from birth who had positive blood cultures for Gram-negative bacteria. Patients were divided into carbapenem-resistant and carbapenem-sensitive groups. Results: During the study, Gram-negative bacteria were isolated from the blood cultures of 113 neonates. Positive Gram-negative bacteria blood cultures and carbapenem-resistant cases were 2.38% and 1.52%, respectively. In these cases, 66 (58.4%) of the infants were males, 100 (88.4%) were preterm, and 74 (65.4%) required mechanical ventilation within the first three days of life. The study found 45 (39.8%) infants with early-onset sepsis. Acinetobacter was the most common isolated organism, while Enterobacter had the lowest isolation rate. Carbapenem resistance was discovered in 72 (63.7%) positive blood cultures. Acinetobacter had the highest prevalence of carbapenem resistance, while Pseudomonas had the lowest. Mortality rates in infants infected with carbapenem resistance bacteria (CRB) were 89.3% compared to 10.7% in those infected with carbapenem-sensitive bacteria (CSB). Conclusions: The frequency of carbapenem-resistant Gram-negative sepsis in our ward was 1.52 percent of all admissions, and Acinetobacter bacteria was the most common cause of this type of neonatal sepsis. Infants infected with CRB had a higher mortality rate than those infected with CSB, 89.3% versus 10.7%. | en |
| DOI | https://doi.org/10.5812/jjm-134278 | en |
| Keyword | Neonate | en |
| Keyword | Sepsis | en |
| Keyword | Gram Negative Bacteria | en |
| Keyword | Antibiotics | en |
| Keyword | Carbapenem | en |
| Publisher | Brieflands | en |
| Title | Frequency, Bacteriological Profile, and Outcome of Neonatal Sepsis with Carbapenem-Resistant Gram-Negative Bacteria at the Tertiary Neonatal Intensive Care Unit, Ahvaz, Iran | en |
| Type | Research Article | en |
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