Sustained Release of Naproxen in a New Kind Delivery System of Carbon Nanotubes Hydrogel
| Author | Xiahui Peng | en |
| Author | Qiang Zhuang | en |
| Author | Dongming Peng | en |
| Author | Qiuli Dong | en |
| Author | Lini Tan | en |
| Author | Feipeng Jiao | en |
| Author | Linqi Liu | en |
| Author | jingyu Liu | en |
| Author | Chenxi Zhao | en |
| Author | Xiaomei Wang | en |
| Issued Date | 2013-10-31 | en |
| Abstract | In this paper, carbon nanotubes (CNTs) were added into chitosan (CS) hydrogels in the form of chitosan modified CNTs (CS-CNTs) composites to prepare carbon nanotubes hydrogels (CNTs-GEL). The products, named CS-MWCNTs, were characterized by scanning electron microscope (SEM) and Fourier transform infrared (FTIR) spectroscopy. Swelling properties and effect of pH on controlled release performance of the two kinds of hydrogels, CNTs- GEL and pure chitosan hydrogels without CNTs (GEL), were investigated respectively. The results showed that CNTs-GEL possess better controlled release performance than GEL. The releasing equilibrium time of CNTs-GEL was longer than that of GEL in both pH = w7.4 and pH=1.2 conditions, although the release ratios of the model drug are similar in the same pH buffer solutions. It is found that release kinetics is better fitted Ritger-Peppas empirical model indicating a fick-diffusion process in pH = 1.2, while in pH = 7.4 it was non-fick diffusion involving surface diffusion and corrosion diffusion processes. | en |
| DOI | https://doi.org/10.22037/ijpr.2013.1390 | en |
| Keyword | Chitosan | en |
| Keyword | Drug delivery | en |
| Keyword | Hydrogel | en |
| Keyword | Multi-walled carbon nanotubes | en |
| Keyword | Release kinetics | en |
| Publisher | Brieflands | en |
| Title | Sustained Release of Naproxen in a New Kind Delivery System of Carbon Nanotubes Hydrogel | en |
| Type | Original Article | en |
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