Proteomic Analysis Reveals an Increase of Neutrophils and TH17-related Proteins Expression in Severe Nodular Acne Lesions of the Back
| Author | Bruno Méhul | en |
| Author | Isabelle Carlavan | en |
| Author | Alexandre Genette | en |
| Author | Alexia Seraidaris | en |
| Author | Béatrice Bertino | en |
| Author | Corinne Ménigot | en |
| Author | Valérie Bourdès | en |
| Author | Brigitte Dréno | en |
| Author | Johannes J. Voegel | en |
| Author | Sandrine Blanchet-Réthoré | en |
| Orcid | Bruno Méhul [0000-0002-3521-6413] | en |
| Issued Date | 2019-09-30 | en |
| Abstract | Background: The etiology and different inflammatory steps associated with the development of an acne nodule remain unsolved. Objectives: This study aimed to investigate the main biological processes involved in acne nodules and compare them to those of papules. Methods: Nodules, papules, and non-involved skin of the back (control) were biopsied to perform proteomic analysis using mass spectrometry, Luminex assay, and elastase staining on skin sections. Results: Many factors involved in the migration and function of immune cells, particularly those impacting leukocytes and neutrophils, were strongly and significantly higher in nodules than in papules and non-involved skin, while several enzymes involved in lipid metabolism were lower. Elastase staining confirmed strong neutrophil infiltration within and around the nodules. Conclusions: Our results highlight the role of neutrophils during nodule formation in severe nodular acne of the back. | en |
| DOI | https://doi.org/10.5812/jssc.101449 | en |
| Keyword | Severe Nodular Acne | en |
| Keyword | Nodule | en |
| Keyword | Neutrophils | en |
| Keyword | Proteomics | en |
| Publisher | Brieflands | en |
| Title | Proteomic Analysis Reveals an Increase of Neutrophils and TH17-related Proteins Expression in Severe Nodular Acne Lesions of the Back | en |
| Type | Research Article | en |