Association between CTLA-4 polymorphism and systemic lupus erythematosus
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Background: Cytotoxic lymphocyte antigen-4 (CTLA-4) plays an important role in regulating T cell activities. CTLA-4 gene polymorphisms are associated with genetic susceptibility to various autoimmune diseases, including systemic lupus erythematosus (SLE). The present study was conducted to analyze the role of CTLA-4 polymorphism at positions −1722TC in patients suffering from SLE.