Effects of Recombinant Follicle Stimulation Hormone on the Ovarian Response in Domestic Cats
| Author | Nahid Changalvaei | en |
| Author | Farid Barati | en |
| Author | Moosa Javdani | en |
| Author | Katayoon Oskouizadeh | en |
| Orcid | Farid Barati [0000-0003-2605-0842] | en |
| Issued Date | 2025-10-31 | en |
| Abstract | Background: Recombinant follicle-stimulating hormone (rFSH) can be administered for the manipulation of the estrus cycle and controlled ovarian stimulation in domestic cats, serving as a crucial model for endangered felid assisted reproductive technology (ART). Objectives: The present study aimed to evaluate the effects of different doses and durations of rFSH administration on ovarian volume and oocyte quality in anestrous domestic cat queens. Methods: A total of 12 anestrous queens were randomly allocated into four groups (n = 3 per group): Three active treatment groups receiving rFSH (Cinnal-F, Iran) intramuscularly and one negative control group (G4, saline). Treatment groups compared dose and duration: G1 (2.0 mg × 2 days), G2 (2.5 mg × 2 days), and G3 (2.5 mg × 4 days). After ovariectomy, ovarian volume was estimated using its dimensions, and oocytes were surgically retrieved 24 hours post-final injection, then counted and graded morphologically (A, B, C/D). Results: The ovarian volume (mm3) was the highest in the 4.0 mg total dose group (right ovary: 178.7 ± 16.8; P = 0.0237; left ovary: 128.2 ± 17.1; P = 0.0405) among all other groups. However, logistic regression analysis revealed no significant differences among any of the groups (G1 - G4) regarding the odds ratios for retrieving high-quality oocytes (grades A and B). Conclusions: The findings showed no efficacy of the applied protocol of rFSH on the ovarian response in terms of oocyte retrieval and follicle development. | en |
| DOI | https://doi.org/10.5812/gct-166982 | en |
| Keyword | Recombinant Follicle-Stimulating Hormone (rFSH) | en |
| Keyword | Ovarian Response | en |
| Keyword | Oocyte Quality | en |
| Keyword | Domestic Cats | en |
| Publisher | Brieflands | en |
| Title | Effects of Recombinant Follicle Stimulation Hormone on the Ovarian Response in Domestic Cats | en |
| Type | Research Article | en |
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