Efficiency of Helicobacter pylori Infection Treatment Protocol: Clarithromycin, Amoxicillin and Omeprazole
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Date
2012-12-24
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Publisher
Brieflands
Abstract
Background:: Helicobacter pylori (H. pylori) is one of the most common pathogen affecting humans, which is approximately infecting 50% of the world population and remains as a significant cause of morbidity and mortality. Since the discovery of Helicobacter pylori in early 1980, many treatment regimens have been developed to effectively treat this infection. Despite the extensive research over the last 25 years the treatment of Helicobacter pylori remains a challenging clinical problem due to its antimicrobial resistance. Objectives:: This study aimed to evaluate Clarithromycin, Amoxicillin and Omeprazole efficiency as a treatment for H. pylori. Patients and Methods:: The patients with clinical features of H. pylori infection and positive serological and clinical test results were entered to the study. Whole of the patients enrolled in the study were given a full two weeks of effective treatment protocol of H. pylori consisted of Clarithromycin (20 mg PO bid), Amoxicillin (1 g PO bid) and Omeprazole (20 mg PO bid) together. Our variables in this study were blood IgG and CagA factor levels, which were collected using serological tests and the H. pylori stool antigen was another variable in the study which was taken from stool tests. Results:: Results showed that the mean level of IgG and CagA of blood samples was lower in the study group than the control one. Moreover, the average level of H. pylori antigen in stool was lower after the treatment. Conclusions:: The result of our study showed that using Clarithromycin, Amoxicillin and Omeprazole for treatment of H. pylori infection can be useful. It is concluded from lower levels of IgG and CagA in blood and H. pylori antigen in stool after treatment compared to the amount of these factors before therapy. Considering all these data, it is obvious that there is an urgent need to found a better therapy and treatment for H. pylori infections in which it cause low bacterial resistance.