Self-emulsifying Drug Delivery System for Improved Dissolution and Oral Absorption of Quetiapine Fumarate: Investigation of Drug Release Mechanism and<i> In-vitro </i>Intestinal Permeability
| Author | Olfa Ben Hadj Ayed | en |
| Author | Mohamed Ali Lassoued | en |
| Author | Badr Bahloul | en |
| Author | Souad Sfar | en |
| Issued Date | 2021-07-31 | en |
| Abstract | In this study, we focused on quetiapine fumarate (QTF), a class II BCS drug. QTF is an atypical antipsychotic used in the treatment of schizophrenia and bipolar disorders. Our objective was to develop a new QTF-loaded self-emulsifying drug delivery system (SEDDS) to improve the dissolution and absorption of the drug. An experimental design approach was used to develop and optimize QTF-loaded SEDDS. The optimized formulation was characterized for droplets size, zeta potential, PDI, and stability. It was then evaluated using an in-vitro combined test for dissolution and Everted gut sac technique. Mathematical modeling and Transmission electron microscopy (TEM) were used to elucidate the mechanism of release. | en |
| DOI | https://doi.org/10.22037/ijpr.2021.114785.15032 | en |
| Keyword | Quetiapine fumarate | en |
| Keyword | self-emulsifying drug delivery system | en |
| Keyword | release kinetics | en |
| Keyword | D-optimal mixture design | en |
| Keyword | Everted Gut Sac | en |
| Publisher | Brieflands | en |
| Title | Self-emulsifying Drug Delivery System for Improved Dissolution and Oral Absorption of Quetiapine Fumarate: Investigation of Drug Release Mechanism and<i> In-vitro </i>Intestinal Permeability | en |
| Type | Original Article | en |
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