Development of a Sensitive and Rapid Method for Determination of Acrylamide in Bread by LC-MS/MS and Analysis of Real Samples in Iran IR

AuthorSamira Eslamizaden
AuthorFarzad Kobarfarden
AuthorKimia Tabiben
AuthorHassan Yazdanpanahen
AuthorJamshid Salamzadehen
Issued Date2020-01-31en
AbstractA new sample preparation procedure and a liquid chromatography–tandem mass spectrometry (LC–MS/MS) method were developed for the quantitative analysis of acrylamide in bread. The method is based on sample extraction in methanol, purification with Carrez solutions and clean- up with Primary Secondary Amine (PSA).The developed method offers an efficient, inexpensive, easy sample preparation and very sensitive procedure for determination of acrylamide in bread. The use of spiked calibration curves for constructing the calibration curve substantially reduced adverse matrix-related effects. Recoveries were between 96 and 105.3%. Good results were obtained with respect to repeatability (RSDsen
DOIhttps://doi.org/10.22037/ijpr.2019.111994.13474en
KeywordFood safetyen
KeywordAcrylamideen
KeywordMethod validationen
KeywordSangak breaden
KeywordLC-MS/MSen
KeywordIran IRen
PublisherBrieflandsen
TitleDevelopment of a Sensitive and Rapid Method for Determination of Acrylamide in Bread by LC-MS/MS and Analysis of Real Samples in Iran IRen
TypeOriginal Articleen

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