Synthesis, Evaluation of Anticancer Activity and QSAR Study of Heterocyclic Esters of Caffeic Acid
| Author | Shima Hajmohamad Ebrahim Ketabforoosh | en |
| Author | Mohsen Amini | en |
| Author | Mohsen Vosooghi | en |
| Author | Abbas Shafiee | en |
| Author | Ebrahim Azizi | en |
| Author | Farzad Kobarfard | en |
| Issued Date | 2013-10-31 | en |
| Abstract | Caffeic acid phenethyl ester (CAPE) suppresses the growth of transformed cells such as human breast cancer cells, hepatocarcinoma , myeloid leukemia, colorectal cancer cells, fibrosarcoma, glioma and melanoma. A group of heterocyclic esters of caffeic acid was synthesized using Mitsunobu reaction and the esters were subjected to further structural modification by electrooxidation of the catechol ring of caffeic acid esters in the presence of sodium benzenesulfinate and sodium toluensulfinate as nucleophiles. Both heterocyclic esters of caffeic acid and their arylsulfonyl derivatives were evaluated for their cytotoxic activity against HeLa, SK-OV-3, and HT-29 cancer cell lines. | en |
| DOI | https://doi.org/10.22037/ijpr.2013.1355 | en |
| Keyword | Caffeic acid | en |
| Keyword | Mitsunobu | en |
| Keyword | Electrooxidation | en |
| Keyword | Cytotoxic activity | en |
| Publisher | Brieflands | en |
| Title | Synthesis, Evaluation of Anticancer Activity and QSAR Study of Heterocyclic Esters of Caffeic Acid | en |
| Type | Original Article | en |
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