The Effect of High-dose Statin on Cardiac Biomarkers Following Lower Limb Vascular Surgery: A Randomized Clinical Trial
| Author | Farahzad Janatmakan | en |
| Author | Fatemeh Javaherforooshzadeh | en |
| Author | Soghra Ganj | en |
| Author | Nozar Nasajian | en |
| Author | Sara Jorirahmadi | en |
| Author | Farhad Soltani | en |
| Author | Seyed Masoud Moosavi | en |
| Orcid | Farahzad Janatmakan [0000-0002-6677-9147] | en |
| Orcid | Fatemeh Javaherforooshzadeh [0000-0002-0803-7268] | en |
| Issued Date | 2025-08-31 | en |
| Abstract | Background: Patients undergoing peripheral vascular surgery frequently present with comorbid cardiovascular disease, where perioperative myocardial ischemia and infarction represent leading causes of morbidity and mortality. Through its plaque-stabilizing properties, atorvastatin may reduce postoperative cardiac complications. Objectives: This study investigated whether preoperative high-dose atorvastatin therapy provides cardioprotective benefits for patients requiring lower limb vascular revascularization. Methods: We conducted a single-center, double-blind, randomized controlled trial at Golestan Hospital (Ahvaz, Iran) between April 2019 and March 2021. Eighty eligible patients were randomly assigned (1:1) via computer-generated allocation concealed in opaque envelopes to receive either high-dose atorvastatin (n = 40) or a conventional dose (control, n = 40). The study maintained triple blinding (participants, surgeons, and assessors). Serial measurements of cardiac biomarkers [troponin I, creatine kinase-MB (CK-MB), creatine phosphokinase (CPK)], renal function (creatinine), and ECG monitoring were performed at 6, 24, and 72 hours postoperatively. Results: Baseline characteristics showed no significant intergroup differences. The atorvastatin group demonstrated significantly lower postoperative levels of troponin I (P < 0.05), CK-MB (P < 0.05), and creatinine (P < 0.05). A transient elevation in CPK levels occurred at 6 hours post-surgery in the treatment group (P < 0.05), which subsequently normalized. These findings support the potential myocardial and renal protective effects of high-dose statin therapy in vascular surgery patients. Conclusions: Perioperative administration of high-dose atorvastatin significantly reduces biochemical markers of cardiac and renal injury following lower extremity vascular procedures. These results suggest statins may improve outcomes in this high-risk surgical population. | en |
| DOI | https://doi.org/10.5812/semj-157631 | en |
| Keyword | Atorvastatin | en |
| Keyword | Troponin I | en |
| Keyword | Creatine Kinase-MB (CK-MB) | en |
| Keyword | Creatine Phosphokinase (CPK) | en |
| Keyword | Creatinine | en |
| Publisher | Brieflands | en |
| Title | The Effect of High-dose Statin on Cardiac Biomarkers Following Lower Limb Vascular Surgery: A Randomized Clinical Trial | en |
| Type | Research Article | en |
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