Serum Levels of Anti-Hepatitis B Surface Antibody Among Vaccinated Population Aged 1 to 18 Years in Ahvaz City Southwest of Iran
| Author | Reza Norouzirad | en |
| Author | Abdol Hussein Shakurnia | en |
| Author | Mohammad-Ali Assarehzadegan | en |
| Author | Amirarsalan Serajian | en |
| Author | Mehdi Khabazkhoob | en |
| Orcid | Abdol Hussein Shakurnia [0000-0003-3354-2917] | en |
| Issued Date | 2014-01-01 | en |
| Abstract | Background: The duration of protection following primary series vaccination against hepatitis B is unknown in children and adolescents. It has been shown that the level of anti-hepatitis B surface antigen antibodies (anti HBs Ab) declines over years after vaccination. Objectives: The aim of this study was to estimate the long-term immunity against hepatitis B virus infection among children and adolescents who had received a complete hepatitis B vaccination series during infancy. Patients and Methods: In a cross-sectional study, the - anti-HBsAb levels of 840 vaccinated children and adolescents were determined by enzyme-linked immunosorbent assay. Results: Hepatitis B seroprotection rates (anti HBsAb ≥ 10 IU/L) among vaccinated children and adolescents aged 1 and 18 years were 90% and 48.9%, respectively. The declining trend of geometric mean titer of anti-HBsAb levels was observed as changed from 272.3 IU/L to 94.1 IU/L in 1 and 18-year-old population, respectively. A significant negative correlation was found between age and anti-HBsAb levels (r = - 0.220, P = 0.0001). Conclusions: The results showed a declining trend in anti-HBsAb titers over the time after vaccination against hepatitis B virus in our region. Further studies are warranted to establish the need for a booster dose in cases that are at risk of hepatitis B virus infection. | en |
| DOI | https://doi.org/10.5812/hepatmon.13625 | en |
| Keyword | <b>Hepatitis B</b> | en |
| Keyword | <b>Vaccination</b> | en |
| Keyword | <b>Iran</b> | en |
| Publisher | Brieflands | en |
| Title | Serum Levels of Anti-Hepatitis B Surface Antibody Among Vaccinated Population Aged 1 to 18 Years in Ahvaz City Southwest of Iran | en |
| Type | Research Article | en |
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