Synergistic Effects of High-Intensity Interval Training and Omega-3 on Modulating Neuroinflammation and Improving Cognitive Function in an Alzheimer's Disease Rat Model
| Author | Mohammad Sadegh Ebrahimi | en |
| Author | Abdolhossein Taheri Kalani | en |
| Author | Fardin Fatahi | en |
| Orcid | Mohammad Sadegh Ebrahimi [0009-0005-5748-1225] | en |
| Orcid | Abdolhossein Taheri Kalani [0000-0003-3668-0266] | en |
| Orcid | Fardin Fatahi [0000-0002-7184-1582] | en |
| Issued Date | 2026-09-30 | en |
| Abstract | Background: Previous studies have demonstrated the role of inflammatory processes in the pathogenesis and progression of Alzheimer's disease (AD). Because currently available medications have insufficient clinical efficacy for the treatment of AD, lifestyle modifications, including exercise and dietary interventions, have become increasingly important for prevention and treatment. Objectives: This study aimed to determine the independent and combined effects of high-intensity interval training (HIIT) and omega-3 (OMG3) supplementation on amyloid beta precursor protein (App) mRNA expression, interleukin-1 beta (IL-1β) gene expression in brain tissue, and spatial memory in rats with AD. Methods: In this experimental study, 30 male Wistar rats aged 12 weeks and weighing 180 - 200 g were randomly assigned to five groups: Control, AD, AD + HIIT, AD + OMG3, and AD + HIIT + OMG3 (combined). To induce the AD model and memory impairment, scopolamine was administered intraperitoneally at 2 mg/kg/day for 9 days. The HIIT protocol consisted of 3 - 4 bouts of treadmill running at 30 m/min, 5 days per week for 8 weeks. The supplemented groups received Mega DHA, containing 10% eicosapentaenoic acid and 50% docosahexaenoic acid, via daily gavage for 8 weeks at a total product dose of 500 mg/kg/day. Forty-eight hours after the final interventions, the rats were sacrificed, and App mRNA and IL-1β gene expression in the brain were measured using real-time polymerase chain reaction. Spatial memory was assessed as the percentage of spontaneous alternation in the Y-maze test. Results: AD induction increased App mRNA and IL-1β gene expression in brain tissue. HIIT and OMG3 supplementation, alone or in combination, were associated with decreased IL-1β gene expression. App mRNA expression was reduced relative to that in the AD group only in the combined group. HIIT and OMG3 supplementation alone did not significantly alter App mRNA expression compared with that in the AD group. Conclusions: These findings suggest that combining HIIT with OMG3 supplementation improves cognitive function in the AD model by modulating neuroinflammation. | en |
| DOI | https://doi.org/10.5812/jkums-172491 | en |
| URI | https://brieflands.com/journals/jkums/articles/172491 | en |
| Keyword | High-Intensity Interval Training | en |
| Keyword | Omega-3 Fatty Acids | en |
| Keyword | Neuroinflammation | en |
| Keyword | Cognitive Function | en |
| Keyword | Alzheimer's Disease | en |
| Publisher | Brieflands | en |
| Title | Synergistic Effects of High-Intensity Interval Training and Omega-3 on Modulating Neuroinflammation and Improving Cognitive Function in an Alzheimer's Disease Rat Model | en |
| Type | Research Article | en |
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