Targeted Screening for Viral Hepatitis Among Various Ethnic Groups in Amsterdam, the Netherlands
| Author | Anne-Marieke Van Dijk | en |
| Author | Cas Isfordink | en |
| Author | Anders Boyd | en |
| Author | Henrike Galenkamp | en |
| Author | Janke Schinkel | en |
| Author | Maria Prins | en |
| Author | R.Bart Takkenberg | en |
| Author | Onno Holleboom | en |
| Author | Marc Van Der Valk | en |
| Issued Date | 2024-12-31 | en |
| Abstract | Background: A significant portion of individuals with hepatitis B virus (HBV) or hepatitis C virus (HCV) in the Netherlands remain undiagnosed, with a majority from migrant backgrounds. Objectives: This study explored whether targeting HBV/HCV screening among individuals with metabolic risk factors enhances screening efficacy within a diverse ethnic cohort. Methods: Participants from six ethnic backgrounds were enlisted from the population-based, prospective HELIUS study in the Netherlands. Included were participants at elevated risk for non-alcoholic fatty liver disease (NAFLD), identified by elevated non-invasive tests (NITs) and/or metabolic risk factors, who were then tested for HBV/HCV. We evaluated screening efficiency, defined as the prevalence of HBV/HCV, by implementing two targeted screening strategies: (1) Testing individuals with elevated NITs; and (2) those with metabolic risk factors. These strategies were compared to a generic testing approach previously utilized in a subset of HELIUS participants. For non-Dutch origin participants, analyses were stratified based on the HBsAg-prevalence in their region of origin: Low (< 2%) and intermediate (2 - 8%). Results: The study included 346 participants at risk for NAFLD, predominantly of Surinamese (n = 180; 45%), Dutch (n = 103; 26%), or Ghanaian (n = 63; 16%) origin. The generic testing approach encompassed 3,050 individuals. Among individuals from low and intermediate HBV-endemic countries, HBsAg-prevalence was 4.7% and 5.3% for those with elevated NITs, 3.9%, and 3.5% for those with metabolic risk factors, and 0.8% and 3.7% for generic testing, respectively. Regarding HCV, two individuals were anti-HCV-positive, with none being HCV-RNA-positive. Conclusions: Targeted screening based on metabolic risk factors or elevated NITs may be more efficient than generic screening among migrants from regions with low HBV prevalence. | en |
| DOI | https://doi.org/10.5812/hepatmon-136838 | en |
| Keyword | Hepatitis B and C | en |
| Keyword | Non-alcoholic Fatty Liver Disease | en |
| Keyword | Targeted Screening | en |
| Publisher | Brieflands | en |
| Title | Targeted Screening for Viral Hepatitis Among Various Ethnic Groups in Amsterdam, the Netherlands | en |
| Type | Research Article | en |
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