The Effects of Co-administration of Immobilization Stress and Aloe vera on Serum Carcinoembryonic Antigen in Rats
| Author | Rahim Ahmadi | en |
| Author | Sedigheh Molaei | en |
| Issued Date | 2015-03-28 | en |
| Abstract | Background:: Immobilization has been used extensively and accepted widely for studying stress-induced alterations. To determine the protective effects of Aloe vera leaf extract, we evaluated the effects of co-administration of immobilization stress and Aloe vera leaf extract on serum level of carcinoembryonic antigen (CEA) tumor marker in male rats. Materials and Methods:: In this experimental study, 45 male Wistar rats were randomly divided into 9 groups of 5 rats in each including: 1) control, 2) normal saline receiving, 3) Aloe vera extract receiving, 4) acutely immobilized, 5) chronically immobilized, 6) acutely immobilized+Aloe vera extract, 7) chronically immobilized+Aloe vera extract, 8) acutely immobilized+normal saline and 9) chronically immobilized + normal saline. The animals were exposed to chronic or acute immobilization stress for 2 h/day or 8 h/day for a period of 3 weeks or one week, respectively. Aloe vera extract (300 mg/kg/day) was fed by gavage feeding orally. Blood samples were collected and following serum collection, CEA level was determined by radioimmunoassay method. Data were compared statistically between groups using ANOVA. Results:: Serum CEA level was significantly increased in acutely (0.640±0.025 ng/mL) or chronically immobilized (0.647±0.023 ng/mL) rats compared with control animals group (0.564±0.014 ng/mL) (p Conclusion:: Our findings indicate that immobilization stress enhances serum CEA level, however, intake of Aloe vera extract can withstand against. | en |
| DOI | https://doi.org/10.17795/zjrms1281 | en |
| Keyword | Carcinoembryonic antigen | en |
| Keyword | Immobilization | en |
| Keyword | Aloe vera | en |
| Keyword | Rat | en |
| Publisher | Brieflands | en |
| Title | The Effects of Co-administration of Immobilization Stress and Aloe vera on Serum Carcinoembryonic Antigen in Rats | en |
| Type | Research Article | en |
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