The Topical Effect of Cappariss spinosa Extract on Burn Wound Healing

Background: Skin burn is one of the most common complications and it still is considered as a major public health issue throughout the world. Objectives: This experiment was conducted in order to study the effects of Capparis spinosa leaves extract (CSLE) cream compared with silver sulfadiazine (SSD) cream to heal burn wounds in rats. Methods: Different parts of the plant (fruit, leaves and petals) were examined for antioxidant activity by 1, 1-diphenyl-2-picrylhydrazyl (DPPH) assay and leave extract was chosen for preparation CSLE cream. Ninety adult male Wistar rats were randomly divided into six groups; each group consists of 15 animals. After sedation, a metal heated in boiling water was used for type II skin burning in 1.5 cm diameter circle on the back of the rats. Group one was not treated and considered as control. The burned areas in 2 - 6 groups were covered twice a day with eucerin, SSD cream and CSLE cream (2.5, 5 and 10 %), respectively. The percentage of the burn wound contraction and histopathological examinations on days 4, 9, and 14 were regarded as the parameters of our study. The obtained data were compared between the groups and days, statistically. Results: Our finding showed that 5 and 10% CSLE cream are more effective to decrease burn wound area compared with other groups. Additionally, there was no significant difference between group 5 and 10% regarding wound-size reduction (P < 0.05). Therefore, 5% CSLE cream is the most effective for wound healing. Conclusions: This study indicated that Capparis spinosa leaves extract has potential effect to accelerate wound healing and decrease inflammation in the treated rats and it can be applied in the future, clinically.