Transcriptional Responses to Cinnamaldehyde in Mycobacterium tuberculosis
| Author | Javad Abkhoo | en |
| Author | Somayeh Jahani | en |
| Author | Mahdieh Shafaghat | en |
| Orcid | Somayeh Jahani [0000-0001-9979-0409] | en |
| Issued Date | 2017-01-01 | en |
| Abstract | Background: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Objectives: Development of the drug resistance is becoming a threat to disease control, which underscores need for new agents targeting M. tuberculosis. Materials and Methods: In this study, analysis of gene expression was performed using real-time polymerase chain reaction (RT- PCR). Results: Results of the current study showed that the minimum inhibitory concentration value of cinnamaldehyde against M. tuberculosis was 200 µg/mL. Moreover, RT-PCR data showed that a total of 25 genes were regulated by the cinnamaldehyde. Of these, 12 genes were up-regulated, and 13 genes were down-regulated. Conclusions: Cinnamaldehyde is a pattern to expand the new anti-TB drugs, because the targets of the cinnamaldehyde are different from those of anti-tubercular agents. | en |
| DOI | https://doi.org/10.17795/iji-38980 | en |
| Keyword | Antimycobacterial Activity | en |
| Keyword | Cinnamaldehyde | en |
| Keyword | Medicinal Plant | en |
| Keyword | <i>Mycobacterium tuberculosis</i> | en |
| Publisher | Brieflands | en |
| Title | Transcriptional Responses to Cinnamaldehyde in Mycobacterium tuberculosis | en |
| Type | Research Article | en |
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