Azole Antifungal Resistance in <i>Candida albicans</i> and <i>Candida glabrata</i> Isolated from Vulvovaginal Candidiasis Patients
| Author | Niloofar Deravi | en |
| Author | Mobina Fathi | en |
| Author | Seyede Nadia Tabatabaeifar | en |
| Author | Parichehr Pooransari | en |
| Author | Bahram Ahmadi | en |
| Author | Gholamreza Shokoohi | en |
| Author | Shirin Yaghoobpoor | en |
| Author | Kimia Vakili | en |
| Author | Ensieh Lotfali | en |
| Author | Saham Ansari | en |
| Orcid | Niloofar Deravi [0000-0002-6965-6927] | en |
| Orcid | Mobina Fathi [0000-0002-4811-3982] | en |
| Orcid | Parichehr Pooransari [0000-0002-8245-6305] | en |
| Orcid | Bahram Ahmadi [0000-0002-7484-4500] | en |
| Orcid | Gholamreza Shokoohi [0000-0003-0868-848X] | en |
| Orcid | Ensieh Lotfali [0000-0001-6709-1320] | en |
| Orcid | Saham Ansari [0000-0002-1623-5803] | en |
| Issued Date | 2021-04-30 | en |
| Abstract | Background: Vulvovaginal candidiasis (VVC) is the most frequent fungal disorder in healthy and normal women. Objectives: The aim of this study was to evaluate the in vitro antifungal susceptibility of clinical isolates Candida albicans and Candida glabrata, the two most common candida species in Iranian patients with VVC. Methods: One hundred and eight clinical isolates of candida, including; C. albicans (n = 77) and C. glabrata: (n = 31) were isolated from the 108 patients with VVC. The in vitro activity of caspofungin (CAS), amphotericin B (AMB), voriconazole (VRC), itraconazole (ITC), fluconazole (FLC), and nystatin (NYS) were determined according to the CLSI M27-A3 and CLSI M27-S4. Results: Our results were shown 8 (25.8 %) and 6 (7.8 %) C. glabrata and C. albicans isolates resistance to FLU, respectively. Furthermore, resistance to VRC and ITC were observed in 8.4%, and 3.7% of all isolates, and six isolates (5.6%) had intermediate MIC to CAS. Conclusions: We reported 8 (25.8 %) and 6 (7.8 %) C. glabrata and C. albicans isolates resistance to FLU, respectively. Furthermore, resistance to VRC and ITC were observed in 8.4% and 3.7% of all isolates, respectively. | en |
| DOI | https://doi.org/10.5812/archcid.106360 | en |
| Keyword | Antifungal Susceptibility | en |
| Keyword | <i>Candida albicans</i> | en |
| Keyword | <i>Candida glabrata</i> | en |
| Keyword | Vulvovaginal Candidiasis | en |
| Publisher | Brieflands | en |
| Title | Azole Antifungal Resistance in <i>Candida albicans</i> and <i>Candida glabrata</i> Isolated from Vulvovaginal Candidiasis Patients | en |
| Type | Research Article | en |
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