Characteristics of Hepatitis B and D Co-infection: A Descriptive Study

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AuthorMahbobeh Hajiabdolbaghien
AuthorZahra Abdiliaeen
AuthorJaleh Bayanien
AuthorMehdi Qaempanahen
AuthorFereshteh Ghiasvanden
Issued Date2021-01-31en
AbstractAbout 5% of cases with chronic hepatitis B virus (HBV) are co-infected with hepatitis D virus (HDV), and this co-infection possesses a high risk for hepatocellular carcinoma (HCC) and cirrhosis. We aimed to evaluate the epidemiological and histopathological characteristics ‎and response to treatment in patients with HBV and HDV co-infection in a hepatitis clinic in Tehran, Iran. In this study, 80 patients were enrolled and evaluated for age, sex, degree of liver fibrosis, virologic status, and response rate. The incidence of co-infection of hepatitis B and D was 4.9% (80/1,631 HBV-infected cases) in our clinic. Thirty-seven (46.25%) patients had liver cirrhosis, and four (5%) patients had HCC. Besides, HDV Ribonucleic Acid (RNA) polymerase chain reaction (PCR) was positive for 31 (38.75 %) patients. Among 30 patients, 14 (46.6%) completed interferon therapy (for equal to or more than 48 weeks) and had a response with undetectable HDV RNA PCR after treatment. According to our results, for cirrhotic patients in HBV/HDV co-infection that was about 46%, it seems that the early detection of HDV antibody (Ab) plays a significant role in the prevention of progressive liver failure, and treatment with interferon can help these patients by improving the prognosis.en
DOIhttps://doi.org/10.5812/hepatmon.101630en
KeywordHepatitis B Virusen
KeywordHBVen
KeywordHepatitis Delta Virusen
KeywordHDVen
KeywordCirrhosisen
PublisherBrieflandsen
TitleCharacteristics of Hepatitis B and D Co-infection: A Descriptive Studyen
TypeBrief Reporten

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