Does Histologic Subtype Influence the Post-Operative Outcome in Spinal Meningioma?
| Author | Hanieh Zham | en |
| Author | Afshin Moradi | en |
| Author | Azadeh Rakhshan | en |
| Author | Alireza Zali | en |
| Author | Ali Rahbari | en |
| Author | Mohammadreza Raee | en |
| Author | Farzad Ashrafi | en |
| Author | Mahsa Ahadi | en |
| Author | Leila Larijani | en |
| Author | Masoud Baikpour | en |
| Author | Maryam Khayamzadeh | en |
| Orcid | Azadeh Rakhshan [0000-0003-2208-4244] | en |
| Orcid | Alireza Zali [0000-0002-2298-2290] | en |
| Orcid | Mahsa Ahadi [0000-0003-3741-1543] | en |
| Orcid | Maryam Khayamzadeh [0000-0002-4663-0118] | en |
| Issued Date | 2016-04-30 | en |
| Abstract | Background: Postoperative outcome of spinal meningiomas is an important issue in surgery decision-making. There are limited and conflicting data in the literature about the prognostic factors influencing recovery, especially about the histopathologic subtypes. Objectives: This study was carried out to evaluate the effect of some of these factors on postoperative outcome. Patients and Methods: This study was performed on 39 patients operated for spinal meningioma between October 1998 and January 2012; their histopathologic subtype was determined according to WHO criteria. The follow up period ranged between 8 - 120 months. The influence of histopathologic subtype, grade, age, sex, surgical approach, local adhesion and anatomical location was assessed according to Frankel classification of neurologic deficit. Results: From a total number of 39 spinal meningiomas, 34 cases were WHO grade I, from which 15 cases were psammomatous, 7 cases were meningothelial, 9 cases were transitional and 3 cases were fibroblastic. Five cases were grade II, 3 of which had clear cell appearance and the remaining 2 had chordoid appearance. The mean age was 51.6 (22 to 76) years; 25 cases were female and 14 cases were male. This study revealed that grade II meningioma cases had poor prognosis in all 5 cases and psammomatous subtype had poor postoperative outcome in 40% of cases while the other subtypes had good outcome in all cases (P = 0.026). Cervical location of the tumor was also related with poor outcome in 37.5% of the cases, while 22.5% had poor outcome in other locations (P = 0.029). Age below and above 45 years and sex had no significant influence on the outcome. Conclusions: Spinal meningiomas of psammomatous type and grade II spinal meningiomas are associated with less favorable postoperative neurologic outcome. Cervical location has also a negative correlation with a good outcome. | en |
| DOI | https://doi.org/10.17795/ijcp-3838 | en |
| Keyword | Spinal Cord Neoplasms | en |
| Keyword | Meningioma | en |
| Keyword | Pathology | en |
| Keyword | Treatment Outcome | en |
| Publisher | Brieflands | en |
| Title | Does Histologic Subtype Influence the Post-Operative Outcome in Spinal Meningioma? | en |
| Type | Research Article | en |