The Effect of Cigarette Smoking and Alcohol Consumption on Survival in Advanced Laryngeal Cancer
| Author | Kamyar Iravani | en |
| Author | Leila Malekmakan | en |
| Author | Aida Doostkam | en |
| Author | Sajjad Soltani | en |
| Issued Date | 2025-12-31 | en |
| Abstract | Background: Laryngeal cancer is the second most common respiratory tract cancer, with a relative 5-year overall survival rate varying by tumor site. Objectives: This study aimed to evaluate the survival of patients based on epidemiological factors, as well as clinical and demographic data. Methods: The study group consisted of 150 patients with advanced laryngeal cancer who underwent total laryngectomy (TL). Demographic data, symptoms, risk factors, tumor characteristics, and postoperative complications were analyzed. Results: The overall survival rates after 1, 3, and 5 years for laryngeal cancer were 99.3%, 97.0%, and 76.5%, respectively. Patients with stage 3 disease had a significantly higher five-year survival rate than those with stage 4 disease (91.0% vs. 68.4%; log-rank: 12.6, P = 0.002). The Kaplan-Meier survival curve showed that 1-year survival was worse among patients with a positive history of alcohol consumption (45.8% vs. 96.2%; log-rank: 13.8, P < 0.001). Although the effect of smoking on survival was not statistically significant due to the small number of non-smoking patients, clinically, a higher percentage of advanced laryngeal cancer patients were smokers. Conclusions: Alcohol consumption and a high tumor stage in patients with laryngeal cancer worsen the prognosis and reduce survival. | en |
| DOI | https://doi.org/10.5812/ijcm-157484 | en |
| Keyword | Laryngeal Neoplasm | en |
| Keyword | Smoking | en |
| Keyword | Laryngectomy | en |
| Keyword | Survival | en |
| Keyword | Risk Factors | en |
| Publisher | Brieflands | en |
| Title | The Effect of Cigarette Smoking and Alcohol Consumption on Survival in Advanced Laryngeal Cancer | en |
| Type | Research Article | en |
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