Targeted Solid Lipid Nanoparticles Formulation for Colon Cancer Treatment and Cytotoxicity Assessment Using HT29 Cell Line
| Author | Eskandar Moghimipour | en |
| Author | Maryam Abedini | en |
| Author | Somayeh Handali | en |
| Orcid | Eskandar Moghimipour [0000-0002-6686-2485] | en |
| Issued Date | 2023-05-31 | en |
| Abstract | Background: Several pharmacological effects have been attributed to thymol. However, limitations such as low solubility in water, low bioavailability, and high volatility have limited its use. Objectives: The present study aimed to prepare and characterize thymol-loaded solid lipid nanoparticles (SLNs) to improve the efficacy of thymol. Methods: Thymol-loaded SLNs were characterized by atomic force microscopy (AFM), differential scanning calorimetry (DSC), and Fourier transformed infrared spectroscopy (FT-IR). Cytotoxicity study and hemolysis assay were also performed. Results: The in vitro drug release showed a sustained manner. Also, SLNs loaded with thymol showed higher cytotoxicity than free thymol, and the hemolysis results indicated the blood biocompatibility of SLNs. Conclusions: As nanocarriers, SLNs can open a new avenue for improving the efficacy of thymol in cancer treatment. | en |
| DOI | https://doi.org/10.5812/jjnpp-135987 | en |
| Keyword | Thymol | en |
| Keyword | Solid Lipid Nanoparticles | en |
| Keyword | Cancer | en |
| Keyword | Drug Delivery System | en |
| Publisher | Brieflands | en |
| Title | Targeted Solid Lipid Nanoparticles Formulation for Colon Cancer Treatment and Cytotoxicity Assessment Using HT29 Cell Line | en |
| Type | Research Article | en |