Cotreatment with Furosemide and Hypertonic Saline Decreases Serum Neutrophil Gelatinase-associated Lipocalin (NGAL) and Serum Creatinine Concentrations in Traumatic Brain Injury: A Randomized, Single-Blind Clinical Trial
| Author | Marziye Jafari | en |
| Author | Shahram Ala | en |
| Author | Kaveh Haddadi | en |
| Author | Abbas Alipour | en |
| Author | Mojtaba Mojtahedzadeh | en |
| Author | Saeid Ehteshami | en |
| Author | Saeid Abediankenari | en |
| Author | Misagh Shafizad | en |
| Author | Ebrahim Salehifar | en |
| Author | Foroogh Khalili | en |
| Issued Date | 2018-07-31 | en |
| Abstract | Acute kidney injury (AKI) occurs both after traumatic brain injury (TBI) and after hypertonic saline administration; furosemide may be useful in preventing AKI indirectly. Serum neutrophil gelatinase-associated lipocalin (sNGAL) is superior to serum creatinine (sCr) in diagnosing early AKI. We compared the administration of hypertonic saline plus furosemide (HTS+F) versus hypertonic saline (HTS), using sCr and sNGAL to investigate kidney injury in patients with TBI. This randomized, single-blind clinical trial was conducted from August 2016 to July 2017 in a neurosurgical intensive care unit, and included patients with a Glasgow Coma Score (GCS) 7-13 and brain edema. One group (n = 22) received hypertonic saline 5% (100 mL over 60 min then 20 mL/h) plus furosemide (40 mg over 60 min then 0.05 mg/kg per hour) for 72 h. The other group (n = 21) received only hypertonic saline 5%, in the same dose as noted above. The sCr and sNGAL concentrations, GCS, and length of stay were measured. Mean ± SD differences were -51.15 (47.07) and 9.96 (64.23) ng/mL for sNGAL and -0.12 (0.22) and -0.005 (0.2) mg/dL for sCr in HTS+F group and HTS group respectively (both p < 0.001). The incidence of stage one AKI according to Improving Global Outcomes (KDIGO) criteria was 4.5% in the HTS+F group and 19.0% in the HTS group (p = 0.16). Hypokalemia was common in both groups. | en |
| DOI | https://doi.org/10.22037/ijpr.2018.2272 | en |
| Keyword | Neutrophil Gelatinase-associated Lipocalin | en |
| Keyword | Serum Creatinine | en |
| Keyword | Furosemide | en |
| Keyword | Hypertonic saline | en |
| Keyword | Traumatic brain injury | en |
| Publisher | Brieflands | en |
| Title | Cotreatment with Furosemide and Hypertonic Saline Decreases Serum Neutrophil Gelatinase-associated Lipocalin (NGAL) and Serum Creatinine Concentrations in Traumatic Brain Injury: A Randomized, Single-Blind Clinical Trial | en |
| Type | Original Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- ijpr-17-1130.pdf
- Size:
- 432.38 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF