Antiparasitic Activity and Essential Oil Chemical Analysis of the <i>Piper Tuberculatum</i> Jacq Fruit
| Author | Valterlúcio dos Santos Sales | en |
| Author | Álefe Brito Monteiro | en |
| Author | Gyllyandeson de Araújo Delmondes | en |
| Author | Emmily Petícia do Nascimento | en |
| Author | Francisco Rodolpho Sobreira Dantas Nóbrega de Figuêiredo | en |
| Author | Cristina Kelly de Souza Rodrigues | en |
| Author | Josefa Fernanda Evangelista de Lacerda | en |
| Author | Cícera Norma Fernandes | en |
| Author | Maysa de Oliveira Barbosa | en |
| Author | Adamo Xenofonte Brasil | en |
| Author | Saulo Relison Tintino | en |
| Author | Maria Celeste Vega Gomez | en |
| Author | Cathia Coronel | en |
| Author | Henrique Douglas Melo Coutinho | en |
| Author | José Galberto Martins da Costa | en |
| Author | Cícero Francisco Bezerra Felipe | en |
| Author | Irwin Rose Alencar de Menezes | en |
| Author | Marta Regina Kerntopf | en |
| Issued Date | 2018-01-31 | en |
| Abstract | With the increase of neglected diseases such as leishmaniasis and Chagas disease, there was a need for the search for new therapeutic alternatives that reduce the harm caused by medicine available for treatment. Thus, this study was performed to investigate the antiparasitic activity of the essential oil from the fruits of Piper tuberculatum Jacq, against lines of Leishmania braziliensis (MHOM/CO/88/UA301), Leishmania infantum (MHOM/ES/92/BCN83) and Trypanosoma cruzi (LC-B5 clone). Before running protocols, an analysis of the chemical composition of essential oil was conducted, which presented monoterpenes and sesquiterpenes. As major constituents, β-pinene and α-pinene were identified. Regarding to antiparasitic activity, the essential oil had an EC50 values of 133.97 µg/mL and 143.59 µg/mL against variations promastigotes of L. infantum and L. braziliensis, respectively. As for trypanocidal activity, the oil showed EC50 value of 140.31 µg/mL against epimastigote form of T. cruzi. Moreover, it showed moderate cytotoxicity in fibroblasts with LC50 value of 204.71 µg/mL. The observed effect may be related to the presence of terpenes contained in the essential oil, since it has its antiparasitic activity proven in the literature. | en |
| DOI | https://doi.org/10.22037/ijpr.2018.2179 | en |
| Keyword | Antiparasitic activity | en |
| Keyword | <i>Piper tuberculatum</i> Jacq | en |
| Keyword | Essential oil | en |
| Keyword | Terpenes | en |
| Keyword | Natural products | en |
| Publisher | Brieflands | en |
| Title | Antiparasitic Activity and Essential Oil Chemical Analysis of the <i>Piper Tuberculatum</i> Jacq Fruit | en |
| Type | Original Article | en |
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