Oxamflatin Induces E-cadherin Expression in HeLa Cervical Carcinoma Cells
| Author | Ebrahim Faghihloo | en |
| Author | Mojdeh Hakemi Vala | en |
| Author | Gita Eslami | en |
| Author | Hossein Goudarzi | en |
| Orcid | Ebrahim Faghihloo [0000-0002-8669-305X] | en |
| Issued Date | 2018-10-31 | en |
| Abstract | Background: Cervical cancer is currently among the most important causes of cancer-related deaths in women. The development of cervical cancer is associated with high-risk human papillomavirus (HPV) infections and a series of epigenetic changes in host cell genome, such as histone acetylation. Furthermore, decreased E-cadherin level has been shown to play a critical role in cancer cell invasion and metastasis. Oxamflatin has been reported to have anti-cancer efficacy. Objectives: We aimed to study the effect of this drug on cervical cancer cell lines, HeLa cells, by assessing E-cadherin level as a marker of cancer invasion susceptibility. Methods: HeLa cells were treated with oxamflatin, and total RNA was obtained. Then, quantitative real-time polymerase chain reaction (PCR) was performed to evaluate E-cadherin expression level in cells treated with oxamflatin. Results: The findings of real-time PCR indicated that oxamflatin increased E-cadherin level in a time- and concentration-dependent manner. The level of E-cadherin significantly increased at the concentrations of 4 mM (for 24 hours after treatment) and 2 and 4 mM (for 48 hours after treatment) in comparison with corresponding control HeLa cells. Conclusions: The present study proposed that oxamflatin may have anti-migratory and anti-invasive potential against cervical cancer cells, which should be further evaluated in future studies. | en |
| DOI | https://doi.org/10.5812/archcid.66977 | en |
| Keyword | Cervical Cancer | en |
| Keyword | HPV | en |
| Keyword | Oxamflatin | en |
| Keyword | E-cadherin | en |
| Keyword | HeLa Cells | en |
| Publisher | Brieflands | en |
| Title | Oxamflatin Induces E-cadherin Expression in HeLa Cervical Carcinoma Cells | en |
| Type | Research Article | en |
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