Systemic Inflammation Response Index and Immune-Inflammation Index as Predictors of Metabolic Syndrome in Obese Children and Adolescents: A Prospective Cross-Sectional Study
| Author | Ozlem Bostan Gayret | en |
| Author | Meltem Erol | en |
| Author | Ovgu Buke | en |
| Author | Abdulrahman Ozel | en |
| Author | Aslıhan Tenekecigil | en |
| Author | Murat Altuntaş | en |
| Orcid | Ozlem Bostan Gayret [0000-0003-4121-8009] | en |
| Orcid | Meltem Erol [0000-0002-7672-1854] | en |
| Orcid | Ovgu Buke [0000-0002-3922-2976] | en |
| Orcid | Abdulrahman Ozel [0000-0001-8947-420X] | en |
| Orcid | Aslıhan Tenekecigil [0000-0002-3893-7136] | en |
| Orcid | Murat Altuntaş [0000-0003-0282-2721] | en |
| Issued Date | 2025-04-30 | en |
| Abstract | Background: With the increase in pediatric obesity, the prevalence of metabolic syndrome (MetS) is rising worldwide. Early identification of children with obesity who are prone to developing MetS is important. Objectives: This study aimed to evaluate the value of the Systemic Immune–Inflammation Index (SII) and the Systemic Inflammatory Response Index (SIRI) in predicting MetS in obese children and adolescents. Methods: This prospective single-center cross-sectional study involved 99 children and adolescents with obesity. The patients were assigned to two groups, MetS+ (n = 42) and MetS- (n = 57), based on the presence of MetS. Complete blood count results from the first visit were evaluated. Results: The white blood cell (WBC), platelet, and neutrophil counts were higher in the MetS+ group (P = 0.003, P = 0.022, and P < 0.001, respectively), while no significant difference was observed in lymphocyte (P = 0.865) and monocyte counts (P = 0.488) between the two groups. When inflammatory parameters were compared, SII (P < 0.001), platelet-to-lymphocyte ratio (PLR) (P = 0.024), neutrophil-to-lymphocyte ratio (NLR) (P = 0.002), and SIRI (P = 0.012) were significantly elevated in the MetS+ group compared to the MetS- group. Binary logistic regression analysis revealed that SII and homeostasis model assessment of insulin resistance (HOMA-IR) were statistically significant risk factors for the presence of MetS (P = 0.003, P = 0.012, respectively). Additionally, a significant positive correlation was found between SII and diastolic blood pressure (DBP) (P = 0.024), high-density lipoprotein cholesterol (HDL-C) (P = 0.019), and fasting plasma glucose (FPG) (P = 0.048), as well as between SIRI and HDL-C (P = 0.044) and FPG (P < 0.001). Receiver operating characteristic analysis of the SII and SIRI ability to predict MetS in adolescents and children with obesity showed that the SII was more discriminative than the SIRI, with a specificity of 0.82, sensitivity of 0.57, and an area under the curve of 0.708. Conclusions: The SII and SIRI can be used for the early diagnosis of MetS in pediatric obesity patients. | en |
| DOI | https://doi.org/10.5812/ijp-148712 | en |
| Keyword | Systemic Inflammation Response Index | en |
| Keyword | Metabolic Syndrome | en |
| Keyword | Childhood Obesity | en |
| Keyword | Systemic Immune–Inflammation Index | en |
| Publisher | Brieflands | en |
| Title | Systemic Inflammation Response Index and Immune-Inflammation Index as Predictors of Metabolic Syndrome in Obese Children and Adolescents: A Prospective Cross-Sectional Study | en |
| Type | Research Article | en |
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