The Therapeutic Effects of Tramadol and Fluoxetine in Premature Ejaculation: A Randomized Clinical Trial

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Background: Premature ejaculation is the most common sexual problem and there are many treatments for this problem. Objectives: The current study aimed to determine and compare the efficacy of tramadol and fluoxetine in males with premature ejaculation. Patients and Methods: In this randomized clinical trial study, 36 males with premature ejaculation attending Booali and Chamran hospitals in Tehran, Iran, in 2013 were enrolled and randomly assigned to receive either 50 mg tramadol or 20 mg fluoxetine 3 - 6 hours before sexual intercourse. Then the intra-vaginal ejaculation latency time (IELT) was compared. Results: Thirty-six subjects with the mean age of 44 ± 19.3 years underwent analysis. Eighteen subjects were treated by fluoxetine and 18 by tramadol. The efficacy of treatment in the two groups showed no significant difference (P > 0.05). There was no significant difference between the two groups in IELT (P > 0.05), but before-after comparisons showed a significant efficacy in the two groups. Conclusions: It was concluded that the efficacy of tramadol and fluoxetine in males with premature ejaculation are the same and both are effective. Both of these drugs are safe to treat premature ejaculation.