Cytotoxic and Apoptogenic Properties of 2-Phenylthiazole-4-Carboxamide Derivatives in Human Carcinoma Cell Lines
| Author | Hanifeh Nazari Tarhan | en |
| Author | LEILA HOSSEINZADEH | en |
| Author | Alireza Aliabadi | en |
| Author | Babak Gholamine | en |
| Author | Alireza Foroumadi | en |
| Issued Date | 2012-06-30 | en |
| Abstract | Apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. Caspases, a family of cysteine-dependent aspartatedirected proteases, play a critical role in the initiation and execution of apoptosis. In this study, cytotoxicity and apoptogenic effect of 2-phenyl 4-carboxamide derivatives were evaluated in SKNMC (human neuroblastoma), MCF-7 (human breast adenocarcinoma) and HT-29 (human colon cancer) cell lines. Cell viability was determined by MTT assay. Also, activation of caspase-3 was evaluated by spectrophotometry. The overall cytotoxicity profiles of derivatives demonstrated that the HT-29 cell line has more sensitivity respect to other cell lines. Moreover, our observations indicated that 3-F and 2-F derivatives and 4-Cl derivative increased caspase-3 activation in three carcinoma cell line compared to control. Collectively, these findings suggest that these derivatives are able to induce apoptosis in cancer cell lines. | en |
| DOI | https://doi.org/ | en |
| Keyword | 2-phenylthiazole-4-carboxamide derivatives | en |
| Keyword | Apoptosis | en |
| Keyword | Caspase-3 | en |
| Publisher | Brieflands | en |
| Title | Cytotoxic and Apoptogenic Properties of 2-Phenylthiazole-4-Carboxamide Derivatives in Human Carcinoma Cell Lines | en |
| Type | Research Article | en |
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