Exercise Training Enhances Expression of Tropomedulin-2 and ADP-Ribosylation Factor 6 in the Cerebellum of Male Wistar Rats
| Author | Seyed Jalal Taherabadi | en |
| Author | Masoud Rahmati | en |
| Orcid | Seyed Jalal Taherabadi [0000-0003-1484-344X] | en |
| Orcid | Masoud Rahmati [0000-0003-4792-027X] | en |
| Issued Date | 2019-09-28 | en |
| Abstract | Background: It has been well documented that exercise training (ET) induces beneficial effects on the central nervous system (CNS); however, the underlying mechanisms are less known. We presumed that actin cytoskeleton regulatory proteins such as ADP-ribosylation factors 6 (ARF6) and tropomodulin 2 (TMOD2) may be important elements of Exercise-Induced Neuroplasticity (EIN). We evaluated this hypothesis in the present study. Methods: We randomly divided 12 male Wistar rats into control (C) and training (T) groups. The T group was exposed to six weeks of moderate-intensity treadmill running. The ARF6 and TMOD2 gene and protein expressions in the cerebellum of male Wistar rats were assessed by the real-time PCR and western blot analysis. Results: The results showed that TMOD2 and ARF6 gene and protein expressions were significantly higher in the T group than in the C group. Conclusions: It seems that chronic treadmill running increases TMOD2 and ARF6 gene and protein expressions in the cerebellum and these changes probably lead to the improvement of brain function. | en |
| DOI | https://doi.org/10.5812/zjrms.89902 | en |
| URI | https://brieflands.com/journals/zjrms/articles/89902 | en |
| Keyword | Actin Cytoskeleton | en |
| Keyword | Treadmill Exercise | en |
| Keyword | ADP-Ribosylation Factors 6 | en |
| Keyword | Tropomodulin-2 | en |
| Keyword | Neural Plasticity | en |
| Publisher | Brieflands | en |
| Title | Exercise Training Enhances Expression of Tropomedulin-2 and ADP-Ribosylation Factor 6 in the Cerebellum of Male Wistar Rats | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- zjrms-21-4-89902.pdf
- Size:
- 232.16 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF