Ocular and Visual Manifestation of Alzheimer’s Disease: A Literature Review II Part: Clinical Studies

Abstract

Context: Visual disturbances are frequent in Alzheimer’s disease (AD) and sometimes AD begins with visual disturbances, therefore many researchers have examined the eyes in order to confirm the diagnosis, to monitor the development of the disease or the response to drugs. Evidence Acquisition: Medline literature until March 2018. Results: Several indications suggest an early involvement of the visual system in AD, yet this evidence remains inconclusive. The reason for this uncertainty is two folds: The poor quality of the studies and the fact that some alterations are not unique to the AD, since they also occur in others degenerative CNS diseases. Conclusions: The eye can be a perfect place for early diagnosis of AD and to evaluate the effectiveness of therapies more studies are needed.