New Diterpenoids from the Aerial Parts of <i>Salvia reuterana</i>
| Author | Mahdi Moridi Farimani | en |
| Author | Mansour Miran | en |
| Author | Samad Nejad Ebrahimi | en |
| Issued Date | 2019-01-31 | en |
| Abstract | The genus Salvia is a valuable origin of structurally diverse terpenoids. In a project directed at structurally interesting bioactive metabolites from Iranian Salvia species, we studied Salvia reuterana. Two new labdane diterpene, 6β, 14α-dihydroxy-15-acetoxysclareol (1), and 14α, 15- dihydroxy sclareol (2), were isolated from the aerial part of the plant. Their structures were established mainly by 1D and 2D NMR spectroscopic techniques, including 1H-1H COSY, HSQC and HMBC methods and HR-ESI-TOFMS spectral data. Compound 1 and 2 were tested for their inhibitory activity toward HeLa and MCF-7 cell lines. Our results showed that S. reuterana is a rich source of labdane diterpenoids. These compounds are rather rare in Salvia species, although they are frequently found in other genera of the Lamiaceae. S. reuterana is a new source of these diterpenoids. | en |
| DOI | https://doi.org/10.22037/ijpr.2019.2314 | en |
| Keyword | <i>Salvia reuterana</i> | en |
| Keyword | Labdane diterpene | en |
| Keyword | Structure elucidation | en |
| Keyword | NMR | en |
| Keyword | Cytotoxicity | en |
| Publisher | Brieflands | en |
| Title | New Diterpenoids from the Aerial Parts of <i>Salvia reuterana</i> | en |
| Type | Original Article | en |
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