Marfan Syndrome and Early-Onset Diabetic Retinopathy: A Case Report
| Author | Y Park Ka | en |
| Author | M Aydin Cristina | en |
| Author | B Mazanderani Adel | en |
| Author | M Johnson | en |
| Author | L Chui | en |
| Author | D Tildesley Hugh | en |
| Issued Date | 2009-01-31 | en |
| Abstract | Diabetic retinopathy is characterized by the proliferation of fibrovascular tissue extending from the retina into the vi-treous cavity. MFS is an autosomal do-minant disorder of the elastic tissue. Al-though MFS clearly manifests with multiple ocular problems, there is no reported association between MFS and diabetic retinopathy. Reported here is the case of 32-year-old male with Marfan Syndrome (MFS) and type 2 diabetes mellitus (DM) presented with an accelerated onset of diabetic retinopathy. Our patient developed diabetic retinopathy only 4 years following the diagnosis of type 2 DM, de-spite excellent glucose control. We suggest that there may be a pathophysiological link between MFS and diabetes involving extracellular matrix components that accelerates and/or augments the retinopathic processes in MFS patients. Specifical-ly, we postulate that increased levels of matrix metalloproteinases (MMP) and transforming growth factor beta (TGF-β) in diabetic retinas fa-cilitate the proteolysis of an already weakened ocular connective tissue in MFS, ultimately lead-ing to early development of ophthalmologic ma-nifestations such as diabetic retinopathy. | en |
| DOI | https://doi.org/ | en |
| Keyword | Marfan syndrome | en |
| Keyword | Diabetic retino-pathy | en |
| Keyword | Type 2 diabetes | en |
| Keyword | Matrix metalloproteinases | en |
| Publisher | Brieflands | en |
| Title | Marfan Syndrome and Early-Onset Diabetic Retinopathy: A Case Report | en |
| Type | Case Report | en |
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