Relationship Between the Underlying Factors and the Treatment Results of Platelet-Rich Plasma (PRP) Injection in Degenerative Knee Disease; A Blinded Randomized Study
| Author | Mohsen Mardani-Kivi | en |
| Author | Ehsan Kazemnejad Leili | en |
| Author | Somaye Esnaashari | en |
| Author | Keyvan Hashemi-Motlagh | en |
| Author | Zoleikha Azari | en |
| Orcid | Mohsen Mardani-Kivi [0000-0002-9437-5756] | en |
| Orcid | Ehsan Kazemnejad Leili [0000-0002-9195-9094] | en |
| Issued Date | 2023-03-31 | en |
| Abstract | Background: To investigate the therapeutic effects of PRP injection + conservative treatment as the intervention group versus normal saline injection + conservative treatment as the control group. Objectives: This study we determined the effects of underlying factors, including age, gender, and body mass index (BMI), on the therapeutic effects of PRP. Methods: In this single-blinded randomized clinical trial, 60 patients with grade 2 knee OA with an age of 40 - 65 years were enrolled. In the intervention group, leukocyte-poor PRP with double spinning, and in the control group, normal saline was injected with a similar protocol. All patients in both groups were also provided with a conservative protocol, including oral celecoxib 100 mg BID for four weeks, modifying physical activity, and 15 sessions of physiotherapy. Results: Demographic characteristics (age, gender, and BMI) and pre-treatment scores were similar between the two groups (all P > 0.05). The WOMAC score was improved from pre-treatment to first week post-treatment in both groups (from 54.89 ± 3.4 to 64.9 ± 3.7 in the intervention group and from 53.7 ± 3.1 to 63.8 ± 3.9 in the control group). It means that PRP + conservative treatment was effective, similar to normal saline + conservative treatment. After adjusting BMI as an underlying variable, it was indicated that in the patients with lower BMI, PRP + conservative provided a better outcome in comparison to saline + conservative treatment (P = 0.014 and P = 0.019, respectively). Also, the comparison of functional scores changes with age as an underlying variable, demonstrating that younger cases obtained a better response from PRP + conservative rather than normal saline + conservative (P = 0.012 and P = 0.007, respectively). Conclusions: PRP seems to be an appropriate choice for treatment of moderate osteoarthritis, especially in younger patients and those with lower BMI. | en |
| DOI | https://doi.org/10.5812/asjsm-120485 | en |
| URI | https://brieflands.com/journals/asjsm/articles/120485 | en |
| Keyword | Platelet Reach Plasma | en |
| Keyword | Degenerative Joint Disease | en |
| Keyword | Knee Osteoarthritis | en |
| Keyword | Injection | en |
| Keyword | Functional Outcome | en |
| Publisher | Brieflands | en |
| Title | Relationship Between the Underlying Factors and the Treatment Results of Platelet-Rich Plasma (PRP) Injection in Degenerative Knee Disease; A Blinded Randomized Study | en |
| Type | Research Article | en |
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