Evaluation of Thyroid Status in COVID-19 Patients: A Retrospective Study
| Author | Mehrangiz Zangeneh | en |
| Author | Salar Javanshir | en |
| Author | Rojin Sarallah | en |
| Author | Yasamin Khosravani-Nezhad | en |
| Author | Mirsaber Sadatamini | en |
| Author | Manije Dezfulinejad | en |
| Author | Yazdanali Faghani | en |
| Orcid | Mehrangiz Zangeneh [0000-0003-1023-9528] | en |
| Orcid | Salar Javanshir [0000-0002-6481-0737] | en |
| Orcid | Rojin Sarallah [0000-0001-8607-346X] | en |
| Orcid | Yasamin Khosravani-Nezhad [0000-0001-6733-3908] | en |
| Orcid | Mirsaber Sadatamini [0000-0002-4911-0206] | en |
| Orcid | Manije Dezfulinejad [0000-0003-4419-6562] | en |
| Orcid | Yazdanali Faghani [0000-0002-6985-347X] | en |
| Issued Date | 2022-10-31 | en |
| Abstract | Background: Angiotensin-converting enzyme 2 (ACE2) is a receptor for SARS-CoV-2, expressed in many organs’ cells, including the thyroid gland. Therefore, COVID-19 may influence thyroid gland function. Objectives: In this article, we aimed to investigate the thyroid gland function in COVID-19 patients and compare them to healthy society to indicate whether thyroid hormones level differ in the disease or not. Methods: This is a single-center retrospective case-control, cross-sectional study on 191 COVID-19 patients and 179 non-COVID-19 individuals as the control group. The status of the thyroid hormones was determined in COVID-19 patients and then compared with the control group. Patients in the case group were divided into 2 groups with and without normal thyroid function and were compared with each other in different aspects of COVID-19. Also, we compared thyroid hormone levels in the patient group with different underlying diseases to show the status of thyroid function in COVID-19 infection. Results: Of the 191 COVID-19 patients, 98 (51.3%) were male, and the mean age of patients was 64 ± 15 years. The thyrotropin level was lower in the patient group than in the control group (1.34 ± 1.29 vs. 2.21 ± 1.99; P < 0.001). The T3 status was meaningfully associated with the level of SpO2 (P < 0.05; r = -0.258). The results demonstrated that thyrotropin (P = 0.653), T3 (P = 0.404), and T4 (P = 0.147) levels were not different in expired and discharged patients. The 2 groups of patients with and without normal thyrotropin levels did not appear significantly different in any aspect of the disease. Conclusions: Thyrotropin level was lower in COVID-19 patients, and the T3 level can predict the SpO2 level. The thyroid gland may be theoretically affected by SARS-CoV-2 infection. | en |
| DOI | https://doi.org/10.5812/iji-132072 | en |
| Keyword | Thyroid | en |
| Keyword | Function | en |
| Keyword | COVID-19 | en |
| Keyword | Patients | en |
| Publisher | Brieflands | en |
| Title | Evaluation of Thyroid Status in COVID-19 Patients: A Retrospective Study | en |
| Type | Research Article | en |
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