Novel Palladium Complex: Cytotoxicity against Cisplatin-resistant K562 Cells

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AuthorAli Jahanian-Najafabadien
AuthorMina Mirianen
AuthorFatemeh Rohanien
AuthorKazem Karamien
AuthorMahboubeh Hosseini Kharaten
AuthorHojjat Sadeghi-Aliabadien
Issued Date2019-07-31en
AbstractToday, development of resistance to anticancer drugs (including cisplatin) is noticed as a major problem. Recently several studies demonstrated that palladium complexes showed remarkable cytotoxic effects against K562 cell line and could be used efficiently for treatment of many human cancers including leukemia. Hereof, K562 cells were made resistant to cisplatin using increasing concentration of cisplatin up to 4.5 mM and then cytotoxic effect of synthesized palladium complex was evaluated on this sub-line using MTT assay. Annexin V/PI staining using flow cytometry and scanning electron microscopy (SEM) were performed to find out the mechanism of the observed cytotoxicity. Results indicated that tested compounds had a noticeable cytotoxic effect on K562 cells 80 times more than cisplatin. Palladium complex also showed significant cytotoxicity on resistant K562 sub-line. Flow cytometry and SEM results revealed that these compounds exert their cytotoxic effect via apoptosis and it could be concluded that the novel synthesized palladium complex might be a good candidate for replacing cisplatin in case of treatment of cisplatin resistant tumors.en
DOIhttps://doi.org/10.22037/ijpr.2019.1100714en
KeywordK562 cellsen
KeywordCisplatin resistanceen
KeywordPalladacyclic complexen
KeywordMTT assayen
KeywordApoptosis assayen
PublisherBrieflandsen
TitleNovel Palladium Complex: Cytotoxicity against Cisplatin-resistant K562 Cellsen
TypeOriginal Articleen

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