Evaluating the Effect of Zingiber <i>Officinalis</i> on Nausea and Vomiting in Patients Receiving Cisplatin Based Regimens

AuthorFanak Fahimien
AuthorKian Khodadaden
AuthorSomayeh Aminien
AuthorFarzaneh Naghibien
AuthorJamshid Salamzadehen
AuthorShadi Baniasadien
Issued Date2011-04-30en
AbstractGinger, the rhizome of Zingiber officinalis, has long been used as herbal medicine for its antiemetic effect. For evaluating the effect of zingiber officinalis on nausea and vomiting (N and V) in patients receiving cisplatin based regimens, a randomized double-blind placebo-controlled cross-over clinical trial was carried out in patients receiving cisplatin in combination with other chemotherapeutic agents. The patients were randomly assigned to receive ginger capsules (rhizome of zingiber officinalis) or placebo in their first cycle of the study. All patients received standard antiemetics for chemotherapy induced nausea and vomiting (CINV). The patients were crossed-over to receive ginger or placebo in their next cycle of chemotherapy. Among 36 eligible patients who received both cycles of treatment, there were no difference in prevalence, severity, and duration of both acute and delayed N and V. Addition of ginger to the standard antiemetic regimen has shown no advantage in reducing acute and delayed N and V in patients with cisplatin-based regimen in this study.en
DOIhttps://doi.org/10.22037/ijpr.2011.969en
KeywordChemotherapyen
KeywordCisplatinen
KeywordGingeren
KeywordNauseaen
KeywordVomitingen
PublisherBrieflandsen
TitleEvaluating the Effect of Zingiber <i>Officinalis</i> on Nausea and Vomiting in Patients Receiving Cisplatin Based Regimensen
TypeOriginal Articleen

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