Serial Liver Stiffness Measurements and Monitoring of Liver-Transplanted Patients in a Real-Life Clinical Practice
| Author | Luca Rinaldi | en |
| Author | Giovanna Valente | en |
| Author | Guido Piai | en |
| Issued Date | 2016-12-01 | en |
| Abstract | Background: Liver transplanted patients need close surveillance for early signs of graft disease. Objectives: Transient elastography can safely be repeated over time, offering serial liver stiffness measurement values. Serial stiffness measurements were compared to single baseline stiffness measurements in predicting the appearance of liver-related clinical events and guiding subsequent clinical decisions. Methods: One hundred and sixty liver transplanted patients were observed for three years in our real-life practice. Results: Liver stiffness measurements were stable in 75% of patients, decreased in 4% of patients, and increased in 21% of patients. The pattern of increased stiffness measurements was associated with both HCV-RNA positive status and the presence of an active biliary complication of liver transplantation and was more predictive of a clinically significant event resulting from any disease of the transplanted liver when compared to a stable pattern or to a single liver stiffness measurement. The procedures that were consequently performed were often diagnostic for unexpected situations, both in HCV-RNA positive and HCV-RNA negative patients. Conclusions: The pattern of longitudinally increased liver stiffness measurements efficiently supported clinical decisions for individualized management strategies. Repeated transient elastography in real-life clinical practice appears to have a practical role in monitoring liver transplanted patients. | en |
| DOI | https://doi.org/10.5812/hepatmon.41162 | en |
| Keyword | Liver Biopsy | en |
| Keyword | Transient Elastography | en |
| Keyword | Liver Fibrosis | en |
| Keyword | Liver Stiffness | en |
| Keyword | Transplantation | en |
| Publisher | Brieflands | en |
| Title | Serial Liver Stiffness Measurements and Monitoring of Liver-Transplanted Patients in a Real-Life Clinical Practice | en |
| Type | Research Article | en |
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