The Selective Cyclooxygenase-2 Inhibitor, the Compound 11b Improves Haloperidol Induced Catatonia by Enhancing the Striatum Dopaminergic Neurotransmission
| Author | Hadi Fathi-Moghaddam | en |
| Author | Mehdi Shafiee Ardestani | en |
| Author | Mostafa Saffari | en |
| Author | Ali Jabbari Arabzadeh | en |
| Author | Mitra Elmi | en |
| Issued Date | 2010-10-31 | en |
| Abstract | A substantial amount of evidence has proposed an important role for Cyclooxygenase-2 (COX-2) enzyme in brain diseases and affiliate disorders. The purpose of this research was studying the effects of COX-2 selective inhibition on haloperidol-induced catatonia in an animal model of drug overdose and Parkinson’s disease (PD). In this study, the effect of acute and Sub-chronic oral administration of a new selective COX-2 inhibitor, i.e. the compound 11b or 1-(Phenyl)-5-(4-methylsulfonylphenyl)-2-ethylthioimidazole, in a dosage of 2, 4 and 8 mg/kg on haloperidol-induced catatonia was evaluated and compared to the standard drug scopolamine (1 mg/kg) by microanalysis of Striatum dopaminergic neurotransmission. The results showed a very high potency for 11b in improving the catalepsy by enhancing the dopaminergic neurotranmission (p < 0.05). In addition, statistical analysis showed the dose- and time-dependent behavior of the observed protective effect of 11b against the haloperidol-induced catatonia and enhancement of the dopaminergic neurotransmission. These findings are additional pharmacological data that suggest the effectiveness of COX-2 inhibition in treatment of schizophreny-associated rigidity. | en |
| DOI | https://doi.org/10.22037/ijpr.2010.904 | en |
| Keyword | Catalepsy | en |
| Keyword | Nigrostriatal | en |
| Keyword | Compound 11b | en |
| Keyword | Dopaminergic neurotransmission | en |
| Publisher | Brieflands | en |
| Title | The Selective Cyclooxygenase-2 Inhibitor, the Compound 11b Improves Haloperidol Induced Catatonia by Enhancing the Striatum Dopaminergic Neurotransmission | en |
| Type | Original Article | en |
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